00100 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 00200 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 00300 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) link:presentationLink link:calculationLink link:definitionLink 00400 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 40401 - Disclosure - Fair value of financial instruments - Fair value on a recurring basis (Details) link:presentationLink link:calculationLink link:definitionLink 40403 - Disclosure - Fair value of financial instruments - Marketable securities portfolio (Details) link:presentationLink link:calculationLink link:definitionLink 40502 - Disclosure - Inventory (Calc2) link:presentationLink link:calculationLink link:definitionLink 40601 - Disclosure - Inventory (Details) link:presentationLink link:calculationLink link:definitionLink 40701 - Disclosure - Property and equipment, net - Property and equipment, net (Details) link:presentationLink link:calculationLink link:definitionLink 40801 - Disclosure - Intangible assets and goodwill (Details) link:presentationLink link:calculationLink link:definitionLink 41101 - Disclosure - Debt - Components of convertible notes (Details) link:presentationLink link:calculationLink link:definitionLink 41202 - Disclosure - Employee benefit plans (Details) link:presentationLink link:calculationLink link:definitionLink 00090 - Document - Document and Entity Information link:presentationLink link:calculationLink link:definitionLink 00105 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 00405 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 10101 - Disclosure - Organization and business link:presentationLink link:calculationLink link:definitionLink 10201 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 10301 - Disclosure - Revenues link:presentationLink link:calculationLink link:definitionLink 10401 - Disclosure - Fair value of financial instruments link:presentationLink link:calculationLink link:definitionLink 10501 - Disclosure - Concentration of credit risk link:presentationLink link:calculationLink link:definitionLink 10601 - Disclosure - Inventory link:presentationLink link:calculationLink link:definitionLink 10701 - Disclosure - Property and equipment, net link:presentationLink link:calculationLink link:definitionLink 10801 - Disclosure - Intangible assets and goodwill link:presentationLink link:calculationLink link:definitionLink 10901 - Disclosure - License agreements link:presentationLink link:calculationLink link:definitionLink 11001 - Disclosure - Stock compensation link:presentationLink link:calculationLink link:definitionLink 11101 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 11201 - Disclosure - Employee benefit plans link:presentationLink link:calculationLink link:definitionLink 11301 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 11401 - Disclosure - Net loss per share link:presentationLink link:calculationLink link:definitionLink 11501 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 20202 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 30403 - Disclosure - Fair value of financial instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 30503 - Disclosure - Concentration of credit risk (Tables) link:presentationLink link:calculationLink link:definitionLink 30603 - Disclosure - Inventory (Tables) link:presentationLink link:calculationLink link:definitionLink 30703 - Disclosure - Property and equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 30803 - Disclosure - Intangible assets and goodwill (Tables) link:presentationLink link:calculationLink link:definitionLink 31003 - Disclosure - Stock compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 31103 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 31203 - Disclosure - Employee benefit plans (Tables) link:presentationLink link:calculationLink link:definitionLink 31403 - Disclosure - Net loss per share (Tables) link:presentationLink link:calculationLink link:definitionLink 40101 - Disclosure - Organization and business (Details) link:presentationLink link:calculationLink link:definitionLink 40201 - Disclosure - Summary of significant accounting policies - Narrative 1 (Details) link:presentationLink link:calculationLink link:definitionLink 40202 - Disclosure - Summary of significant accounting policies - Narrative 2 (Details) link:presentationLink link:calculationLink link:definitionLink 40301 - Disclosure - Revenues (Details) link:presentationLink link:calculationLink link:definitionLink 40402 - Disclosure - Fair value of financial instruments - Rollforward of Level 3 liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 40501 - Disclosure - Concentration of credit risk (Details) link:presentationLink link:calculationLink link:definitionLink 40702 - Disclosure - Property and equipment, net - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 40901 - Disclosure - License agreements - Novartis (Details) link:presentationLink link:calculationLink link:definitionLink 40902 - Disclosure - License agreements - Lilly (Details) link:presentationLink link:calculationLink link:definitionLink 40903 - Disclosure - License agreements - Agenus (Details) link:presentationLink link:calculationLink link:definitionLink 40904 - Disclosure - License agreements - Hengrui (Details) link:presentationLink link:calculationLink link:definitionLink 40905 - Disclosure - License agreements - Merus (Details) link:presentationLink link:calculationLink link:definitionLink 40906 - Disclosure - License agreements - Calithera (Details) link:presentationLink link:calculationLink link:definitionLink 40907 - Disclosure - License agreements - MacroGenics (Details) link:presentationLink link:calculationLink link:definitionLink 40908 - Disclosure - License agreements - Syros (Details) link:presentationLink link:calculationLink link:definitionLink 41001 - Disclosure - Stock compensation (Details) link:presentationLink link:calculationLink link:definitionLink 41002 - Disclosure - Stock compensation - Option activity (Details) link:presentationLink link:calculationLink link:definitionLink 41003 - Disclosure - Stock compensation - RSU and PSU award activity (Details) link:presentationLink link:calculationLink link:definitionLink 41004 - Disclosure - Stock compensation - RSU and PSU Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 41102 - Disclosure - Debt - Carrying amount and Fair Value (Details) link:presentationLink link:calculationLink link:definitionLink 41103 - Disclosure - Debt - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 41201 - Disclosure - Employee Benefit Plans - Defined Contribution Plan (Details) link:presentationLink link:calculationLink link:definitionLink 41301 - Disclosure - Income taxes (Details) link:presentationLink link:calculationLink link:definitionLink 41302 - Disclosure - Income Taxes - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 41401 - Disclosure - Net loss per share (Details) link:presentationLink link:calculationLink link:definitionLink 41501 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink 30303 - Disclosure - Revenues (Tables) link:presentationLink link:calculationLink link:definitionLink 41005 - Disclosure - Stock compensation - Share activity (Details) link:presentationLink link:calculationLink link:definitionLink