Document and Entity Information Statement [Table] Statement [Line Items] Statement Condensed Consolidated Statements of Cash Flows Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Current Reporting Status Entity Filer Category Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus CONDENSED CONSOLIDATED BALANCE SHEETS Assets [Abstract] ASSETS Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Marketable Securities, Current Marketable securities-available-for-sale Accounts Receivable, Net Accounts receivable Inventory, Net Inventory Inventories - current Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Total current assets Restricted Cash and Investments, Noncurrent Restricted cash and investments LongTermInvestments Long term investment Long term investments Inventory, Noncurrent Inventory Inventories - non -current Property, Plant and Equipment, Net Property and equipment, net Property and Equipment, net Other Intangible Assets, Net Other intangible assets, net Goodwill Other Assets, Noncurrent Other assets, net Assets Total assets Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT) Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation Interest Payable, Current Interest payable Accrued Liabilities, Current Accrued and other current liabilities Convertible Debt, Current Convertible senior notes Less current portion Business Combination, Contingent Consideration, Liability, Current Acquisition-related contingent consideration Liabilities, Current Total current liabilities Convertible Debt, Noncurrent Convertible senior notes Convertible senior notes noncurrent Business Combination, Contingent Consideration, Liability, Noncurrent Acquisition-related contingent consideration Other Liabilities, Noncurrent Other liabilities Liabilities Total liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of March 31, 2018 and December 31, 2017 Common Stock, Value, Issued Common stock, $0.001 par value; 400,000,000 shares authorized; 211,888,186 and 211,262,906 shares issued and outstanding as of March 31, 2018 and December 31, 2017, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Ending balance, Shares outstanding Beginning balance, Shares outstanding Common stock, shares outstanding CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS Revenues [Abstract] Revenues: Revenues. Total revenues Costs and Expenses [Abstract] Costs and expenses: Cost of Revenue Cost of product revenues (including definite-lived intangible amortization) Research and Development Expense Research and development Research and development expense Selling, General and Administrative Expense Selling, general and administrative Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Change in fair value of acquisition-related contingent consideration Change in fair value of contingent consideration Costs and Expenses Total costs and expenses Operating Income (Loss) Loss from operations Other Nonoperating Income (Expense) Other income (expense), net Interest Expense Interest expense Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI). Equity Securities, FV-NI, Unrealized Gain (Loss) Unrealized (gain) loss on long term investments Unrealized gain (loss) on long term investments Induced Conversion of Convertible Debt Expense Expense related to senior note conversions Expense related to senior note conversions Gain (Loss) on Repurchase of Debt Instrument Loss on repurchase of convertible senior notes Debt exchange expense Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Loss before provision (benefit) for income taxes Income Tax Expense (Benefit) Provision (benefit) for income taxes Income tax (benefit) expense Net Income (Loss) Available to Common Stockholders, Basic Net income Net loss Net loss Earnings Per Share, Basic and Diluted Basic and diluted net loss per share (in dollars per share) Weighted Average Number of Shares Outstanding, Basic and Diluted Shares used in computing basic and diluted net loss per share (in shares) CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized loss on marketable securities, net of tax Amount after tax, before reclassification adjustments, of unrealized holding gain (loss) on long term equity investments consisting of investments in common stock of publicly-held companies with whom we have entered into collaboration and license agreements. Other Comprehensive Income Unrealized Holding Gain Loss on Long Term Equity Investments Arising During Period Net of Tax Unrealized gain on long term investment, net of tax (Note 2) Other Comprehensive (Income) Loss, Pension and Other Postretirement Benefit Plans, Adjustment, Net of Tax Defined benefit pension obligations, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Debt Instrument [Axis] Debt Instrument Name [Domain] Debt Instrument, Name [Domain] Represents a contractual arrangement to borrow and repay the amount under convertible senior notes at an interest rate of 0.375 percent, which are due in 2018. Convertible Senior Notes0.375 Percent Due2018 [Member] Convertible Senior Notes 0.375 Percent Due 2018 Represents a contractual arrangement to borrow and repay the amount under convertible senior notes at an interest rate of 1.25 percent, which are due in 2020. Convertible Senior Notes1.25 Percent Due2020 [Member] Convertible Senior Notes 1.25 Percent Due 2020 Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities: Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash provided by (used in) operating activities: Depreciation, Depletion and Amortization Depreciation and amortization Share-based Compensation Stock-based compensation Other Noncash Income (Expense) Other, net Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Inventories Inventory Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued and other liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities: Payments for (Proceeds from) Investments Purchase of long term investments Payments to Acquire Productive Assets Capital expenditures Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds from Sale and Maturity of Marketable Securities Sale and maturities of marketable securities Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities: Proceeds from Stock Plans Proceeds from issuance of common stock under stock plans Represents the amount paid in connection with senior not conversions. Payment In Connection Of Conversion Of Convertible Debt Cash paid in connection with senior note conversions The cash outflow with regard to the contingent consideration during the period. Payment of Contingent Consideration Payment of contingent consideration Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Foreign currency translation change Effect of exchange rates on cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net decrease in cash, cash equivalents, restricted cash and investments Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents, restricted cash and investments at end of period Cash, cash equivalents, restricted cash and investments at beginning of period Supplemental Cash Flow Information [Abstract] Supplemental Schedule of Cash Flow Information Income Taxes Paid, Net Income taxes paid Debt Conversion, Converted Instrument, Amount Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes Capital Expenditures Incurred but Not yet Paid Unpaid purchases of property and equipment Debt Instrument, Interest Rate, Stated Percentage Interest rate of debt (as a percent) Organization and business Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block] Organization and business Summary of significant accounting policies Significant Accounting Policies [Text Block] Summary of significant accounting policies Revenues Revenue from Contract with Customer [Text Block] Revenues Fair value of financial instruments. Fair Value Disclosures [Text Block] Fair value of financial instruments Concentration of credit risk Concentration Risk Disclosure [Text Block] Concentration of credit risk Inventory Inventory Disclosure [Text Block] Inventory Property and equipment, net Property, Plant and Equipment Disclosure [Text Block] Property and equipment, net Intangible assets and goodwill Goodwill and Intangible Assets Disclosure [Text Block] Intangible assets and goodwill License agreements This element may be used to describe all significant license agreements of the reporting entity. License Agreements [Text Block] License agreements Stock compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock compensation Debt Debt Disclosure [Text Block] Debt Employee benefit plans Pension and Other Postretirement Benefits Disclosure [Text Block] Employee benefit plans Income taxes Income Tax Disclosure [Text Block] Income taxes Net loss per share Earnings Per Share [Text Block] Net loss per share Subsequent Events Subsequent Events [Text Block] Subsequent Events Basis of Accounting, Policy [Policy Text Block] Basis of presentation Consolidation, Policy [Policy Text Block] Principles of Consolidation Foreign Currency Transactions and Translations Policy [Policy Text Block] Foreign Currency Translation Use of Estimates, Policy [Policy Text Block] Use of Estimates Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentrations of Credit Risk Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Marketable Securities, Policy [Policy Text Block] Marketable Securities-Available-for-Sale Trade and Other Accounts Receivable, Policy [Policy Text Block] Accounts Receivable Inventory, Policy [Policy Text Block] Inventory Consolidation, Variable Interest Entity, Policy [Policy Text Block] Variable Interest Entities Disclosure of accounting policy for long term investments in financial asset. Long Term Investment [Policy Text Block] Long Term Equity Investments Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Lease, Policy [Policy Text Block] Lease Accounting Intangible Assets, Finite-Lived, Policy [Policy Text Block] Other Intangible Assets, net Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long-Lived Assets Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block] Goodwill Income Tax, Policy [Policy Text Block] Income Taxes Debt, Policy [Policy Text Block] Financing Costs Related to Long-term Debt Disclosure of accounting policy related to grant accounting. Grant Accounting [Policy Text Block] Grant Accounting Earnings Per Share, Policy [Policy Text Block] Net Income (Loss) Per Share Comprehensive Income, Policy [Policy Text Block] Accumulated Other Comprehensive Income (Loss) Disclosure of accounting policy for revenue from contract with customer. Revenue From Contract With Customer Policy Text Block Revenue Recognition Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock Compensation Disclosure of accounting policy for acquisition related contingent consideration. Business Combination Contingent Consideration [Policy Text Block] Acquisition-Related Contingent Consideration New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Disaggregation of Revenue [Table Text Block] Revenues Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Schedule of fair value of assets and liabilities measured on recurring basis Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block] Schedule of rollforward of Level 3 liabilities Fair Value, Assets Measured on Recurring Basis [Table Text Block] Schedule of fair value of assets measured on recurring basis Fair Value, Liabilities Measured on Recurring Basis [Table Text Block] Schedule of fair value of liabilities measured on recurring basis Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). Debt Securities, Available-for-sale [Table Text Block] Summary of marketable securities portfolio Tabular disclosure of the nature of a concentration, a benchmark to which it is compared, and the percentage that the risk is to the benchmark, related to the collaborative partners. Schedules of Concentration of Risk by Risk Factor Related to Collaborative Partners [Table Text Block] Schedule of concentration of credit risk related to collaborative partners Tabular disclosure of the nature of a concentration, a benchmark to which it is compared, and the percentage that the risk is to the benchmark, related to the specialty pharmaceutical customers. Schedules of Concentration of Risk by Risk Factor Related to Specialty Pharmaceutical Customers [Table Text Block] Schedule of concentration of credit risk related to specialty pharmacy customers Tabular disclosure of carrying amount of inventories as of the balance sheet date. Schedule of Inventory [Table Text Block] Schedule of inventory Property, Plant and Equipment [Table Text Block] Schedule of property and equipment, net Represent Schedule Of Finite Lived And Indefinite Lived Intangible Assets By Major Class. Schedule Of Finite Lived And Indefinite Lived Intangible Assets By Major Class [Table Text Block] Schedule of intangible assets, net Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block] Schedule of estimated aggregate amortization expense Tabular disclosure of the significant assumptions used during the year to estimate the fair value of employee stock options plan and employee stock purchase plans, including, but not limited to: (a) expected term, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. Schedule of Share Based Payment Award, Stock Options and Employee Stock Purchase Plan Valuation Assumptions [Table Text Block] Schedule of valuation assumptions used for valuation of fair value of stock compensation granted Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] Schedule of option activity under the 2010 Stock Plan Tabular disclosure represents the schedule of share based compensation other than stock options activity. Schedule of RSU award activity under the 2010 Stock Plan Schedule of Common Stock Outstanding Roll Forward [Table Text Block] Schedule of summary of share activity Schedule of Long-term Debt Instruments [Table Text Block] Schedule of components of convertible notes