Document and Entity Information Document Information [Table] Document Information [Line Items] Document Type Document Annual Report Document Transition Report Document Period End Date Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company ICFR Auditor Attestation Flag Entity Shell Company Entity Public Float Entity Common Stock, Shares Outstanding Auditor Name Auditor Firm ID Auditor Location Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Entity Central Index Key Amendment Flag CONSOLIDATED BALANCE SHEETS Statement [Table] Statement [Line Items] Statement Condensed Consolidated Statements of Cash Flows Assets [Abstract] ASSETS Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Debt Securities, Available-for-sale, Current Marketable securities-available-for-sale (amortized cost $291,871 and $288,199 as of December 31, 2021 and 2020, respectively; allowance for credit losses $0 as of December 31, 2021 and 2020) Accounts Receivable, Net Accounts receivable Inventory, Net Inventory Inventories - current Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Current assets Total current assets Restricted Cash and Investments, Noncurrent Restricted cash and investments Long-term Investments Long term investments Long term investments (Note 6) Inventory, Noncurrent Inventory Inventories-noncurrent Property, Plant and Equipment, Net Property and equipment, net Property and Equipment, net Finance Lease, Right-of-Use Asset Finance lease right-of-use assets, net Other Intangible Assets, Net Other intangible assets, net Goodwill Deferred Income Tax Assets, Net Deferred income tax asset Other Assets, Noncurrent Other assets, net Assets Total assets Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS' EQUITY Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation Accrued Liabilities, Current Accrued and other current liabilities Total accrued and other current liabilities Finance Lease, Liability, Current Finance lease liabilities Finance lease liabilities, current Business Combination, Contingent Consideration, Liability, Current Acquisition-related contingent consideration Liabilities, Current Current liabilities Total current liabilities Business Combination, Contingent Consideration, Liability, Noncurrent Acquisition-related contingent consideration Finance Lease, Liability, Noncurrent Finance lease liabilities, noncurrent Finance lease liabilities Other Liabilities, Noncurrent Other liabilities Liabilities Total liabilities Commitments and Contingencies. Commitments and contingencies (Note 15) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of December 31, 2021 and 2020 Common Stock, Value, Issued Common stock, $0.001 par value; 400,000,000 shares authorized; 221,084,433 and 219,489,329 shares issued and outstanding as of December 31, 2021 and 2020, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Balances Balances Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Debt Securities, Available-for-sale, Amortized Cost, Current Marketable securities-amortized cost Debt Securities, Available-for-sale, Allowance for Credit Loss Marketable securities-allowance for credit losses Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding CONSOLIDATED STATEMENTS OF OPERATIONS Products and Services [Axis] Products and Services [Domain] Product revenues, net Product royalty revenues Represents information pertaining to milestone and contract revenues. Milestone and contract revenues Revenues [Abstract] Revenues: Revenues. Total revenues Costs and Expenses [Abstract] Costs and expenses: Cost of Revenue Cost of product revenues (including definite-lived intangible amortization) Research and Development Expense Research and development Research and development expense Selling, General and Administrative Expense Selling, general and administrative Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Change in fair value of acquisition-related contingent consideration The expense recognized during the reporting period for collaboration loss sharing. Collaboration Loss Sharing Expense Collaboration loss sharing Costs and Expenses Total costs and expenses Operating Income (Loss) Income (loss) from operations Other Nonoperating Income (Expense) Other income (expense), net Interest Expense Interest expense Equity Securities, FV-NI, Unrealized Gain (Loss) Unrealized loss (gain) on long term investments Unrealized (loss) gain on long term investments Unrealized gain (loss) on long term investments Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Income (loss) before (benefit) provision for income taxes Income (loss) before (benefit) provision for income taxes Income Tax Expense (Benefit) (Benefit) provision for income taxes (Benefit) provision for income taxes Net Income (Loss) Attributable to Parent Net income (loss) Net income (loss) Earnings Per Share, Basic and Diluted [Abstract] Net income (loss) per share: Earnings Per Share, Basic Basic Basic net income (loss) per share Earnings Per Share, Diluted Diluted Diluted net income (loss) per share Weighted Average Number of Shares Outstanding, Diluted [Abstract] Shares used in computing net income (loss) per share: Weighted Average Number of Shares Outstanding, Basic Weighted average common shares outstanding Basic Weighted Average Number of Shares Outstanding, Diluted Weighted average shares used to compute diluted net income (loss) per share Diluted CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive Income (loss): Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation (loss) gain Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized (loss) gain on marketable securities, net of tax Other Comprehensive (Income) Loss, Pension and Other Postretirement Benefit Plans, Adjustment, Net of Tax Defined benefit pension obligations, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive income (loss) Other comprehensive income (loss) Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive income (loss) CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Common Stock [Member] Additional Paid-in Capital [Member] Accumulated Other Comprehensive Income (Loss) [Member] Retained Earnings [Member] Cumulative Effect, Period of Adoption [Axis] Cumulative Effect, Period of Adoption [Domain] Adoption of ASU Adjustments for New Accounting Pronouncements [Axis] Type of Adoption [Domain] ASU 2016-02 Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Value stock issued during the period as a result of the exercise of stock options and restricted stock units and the aggregate change in value for stock issued during the period as a result of employee stock purchase plan. Stock Issued During Period Value Stock Options and Restricted Stock Units Exercised and Employee Stock Purchase Plan Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units and performance shares, net of shares withheld for taxes and shares of Common Stock under the ESPP Stock Issued During Period, Value, Issued for Services Issuance of shares of Common Stock for services rendered Stock Issued During Period, Value, Conversion of Convertible Securities Issuance of shares of Common Stock upon conversion of Convertible Senior Notes Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock compensation Debt Instrument [Axis] Debt Instrument, Name [Domain] Represents a contractual arrangement to borrow and repay the amount under convertible senior notes at an interest rate of 1.25 percent, which are due in 2020. Convertible Senior Notes 1.25 Percent Due 2020 Stock Issued During Period, Shares, Share-based Compensation, Net of Forfeitures Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units and performance shares Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of shares of Common Stock under the ESPP Number of shares issued Stock Issued During Period, Shares, Issued for Services Issuance of shares of Common Stock for services rendered Stock Issued During Period, Shares, Conversion of Convertible Securities Issuance of shares of Common Stock upon conversion of convertible senior notes CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities: Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net income (loss) Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net income to net cash provided by operating activities: Depreciation, Depletion and Amortization Depreciation and amortization Share-based Compensation Stock-based compensation Deferred income taxes Deferred income taxes (including benefit from valuation allowance release) Other Noncash Income (Expense) Other, net Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Inventories Inventory Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued and other liabilities Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities: Payments to Acquire Long-term Investments Purchase of long term investments Proceeds from Sale of Long-term Investments Sale of long term investments Payments to Acquire Productive Assets Capital expenditures Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds from Sale and Maturity of Marketable Securities Sale and maturities of marketable securities Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities: Proceeds from Stock Plans Proceeds from issuance of common stock under stock plans Payment, Tax Withholding, Share-based Payment Arrangement Tax withholdings related to restricted and performance share vesting Finance Lease, Principal Payments Payment of finance lease liabilities Cash paid for financing lease liabilities in financing cash flows The cash outflow with regard to the contingent consideration during the period. Payment of Contingent Consideration Payment of contingent consideration Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Foreign currency translation change Effect of exchange rates on cash, cash equivalents, restricted cash and investments Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase (decrease) in cash, cash equivalents, restricted cash and investments Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents, restricted cash and investments at end of period Cash, cash equivalents, restricted cash and investments at beginning of period Supplemental Cash Flow Information [Abstract] Supplemental Schedule of Cash Flow Information Interest Paid, Net Interest paid Income Taxes Paid, Net Income taxes paid Debt Conversion, Converted Instrument, Amount Reclassification to common stock and additional paid in capital in connection with conversion/exchange of debt instruments Capital Expenditures Incurred but Not yet Paid Unpaid purchases of property and equipment Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Leased assets obtained in exchange for new operating lease liabilities Right-of-Use Asset Obtained in Exchange for Finance Lease Liability Leased assets obtained in exchange for new finance lease liabilities Debt Instrument, Interest Rate, Stated Percentage Interest rate of debt (as a percent) Organization and Summary of Significant Accounting Policies Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block] Organization and Summary of Significant Accounting Policies Revenues Revenue from Contract with Customer [Text Block] Revenues Fair Value of Financial Instruments Fair Value Disclosures [Text Block] Fair Value of Financial Instruments Concentrations of Credit Risk and Current Expected Credit Losses