Document and Entity Information Statement [Table] Statement [Line Items] Statement Consolidated Statements of Cash Flows Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus CONSOLIDATED BALANCE SHEETS Assets [Abstract] ASSETS Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Marketable Securities, Current Marketable securities—available-for-sale Accounts Receivable, Net Accounts receivable Inventory, Net Inventory Inventories - current Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Assets, Current Current assets Total current assets Restricted Cash and Investments, Noncurrent Restricted cash and investments LongTermInvestments Long term investment Long term investments Inventory, Noncurrent Inventory Inventories - non -current Property, Plant and Equipment, Net Property and equipment, net Property and Equipment, net Other Intangible Assets, Net Other intangible assets, net Goodwill Other Assets, Noncurrent Other assets, net Assets Total assets Liabilities and Equity [Abstract] LIABILITIES AND STOCKHOLDERS’ EQUITY Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued compensation Interest Payable, Current Interest payable Accrued Liabilities, Current Accrued and other current liabilities Total accrued and other current liabilities Convertible Debt, Current Convertible senior notes Less current portion Business Combination, Contingent Consideration, Liability, Current Acquisition-related contingent consideration Liabilities, Current Current liabilities Total current liabilities Convertible Debt, Noncurrent Convertible senior notes Convertible senior notes noncurrent Business Combination, Contingent Consideration, Liability, Noncurrent Acquisition-related contingent consideration Other Liabilities, Noncurrent Other liabilities Liabilities Total liabilities Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding as of December 31, 2018 and December 31, 2017 Common Stock, Value, Issued Common stock, $0.001 par value; 400,000,000 shares authorized; 213,274,660 and 211,262,906 shares issued and outstanding as of December 31, 2018 and December 31, 2017, respectively Additional Paid in Capital, Common Stock Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Balances Balances Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, shares authorized Preferred Stock, Shares Issued Preferred stock, shares issued Preferred Stock, Shares Outstanding Preferred stock, shares outstanding Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, shares authorized Common Stock, Shares, Issued Common stock, shares issued Common Stock, Shares, Outstanding Common stock, shares outstanding CONSOLIDATED STATEMENTS OF OPERATIONS Revenues [Abstract] Revenues: Revenues. Total revenues Costs and Expenses [Abstract] Costs and expenses: Cost of Revenue Cost of product revenues (including definite-lived intangible amortization) Research and Development Expense Research and development Research and development expense Selling, General and Administrative Expense Selling, general and administrative Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability Change in fair value of acquisition-related contingent consideration Costs and Expenses Total costs and expenses Operating Income (Loss) Income (loss) from operations Investment Income, Net Other income (expense), net Interest Expense Interest expense Amount of unrealized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI). Equity Securities, FV-NI, Unrealized Gain (Loss) Unrealized loss on long term investments Unrealized loss on long term investments Unrealized gain (loss) on long term investments Induced Conversion of Convertible Debt Expense Expense related to senior note conversions Expense related to senior note conversions Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Extraordinary Items, Noncontrolling Interest Income (loss) before income taxes Income (loss) before provision for income taxes Income Tax Expense (Benefit) Provision for income taxes Provision (benefit) for income taxes Net Income (Loss) Attributable to Parent Net income Net income (loss) Net income (loss) Earnings Per Share, Basic and Diluted [Abstract] Net income (loss) per share: Earnings Per Share, Basic Basic Basic net income (loss) per share Earnings Per Share, Diluted Diluted Diluted net income (loss) per share Weighted Average Number of Shares Outstanding, Diluted [Abstract] Shares used in computing net income (loss) per share: Weighted Average Number of Shares Outstanding, Basic Weighted average common shares outstanding Shares used in computation of basic net income (loss) per share Basic Weighted Average Number of Shares Outstanding, Diluted Weighted average shares used to compute diluted net income (loss) per share Shares used in computation of diluted net income (loss) per share Diluted CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive loss Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax, Portion Attributable to Parent Foreign currency translation Other Comprehensive Income (Loss), Unrealized Holding Gain (Loss) on Securities Arising During Period, Net of Tax Unrealized gain on marketable securities, net of tax Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax Reclassification adjustment for realized loss on marketable securities Other Comprehensive (Income) Loss, Pension and Other Postretirement Benefit Plans, Adjustment, Net of Tax Defined benefit pension obligations, net of tax Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent Other comprehensive loss Other comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive income (loss) CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Equity Component [Domain] Common Stock [Member] Common Stock Additional Paid In Capital [Member] Additional Paid-in Capital Accumulated Other Comprehensive Income [Member] Accumulated Other Comprehensive Income (Loss) Retained Earnings [Member] Accumulated Deficit Debt Instrument [Axis] Debt Instrument Name [Domain] Debt Instrument, Name [Domain] Represents a contractual arrangement to borrow and repay the amount under convertible senior notes at an interest rate of 1.25 percent, which are due in 2020. Convertible Senior Notes1.25 Percent Due2020 [Member] Convertible Senior Notes 1.25 Percent Due 2020 Represents a contractual arrangement to borrow and repay the amount under convertible senior notes at an interest rate of 0.375 percent, which are due in 2018. Convertible Senior Notes0.375 Percent Due2018 [Member] Convertible Senior Notes 0.375 Percent Due 2018 Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Value stock issued during the period as a result of the exercise of stock options and restricted stock units and the aggregate change in value for stock issued during the period as a result of employee stock purchase plan. Stock Issued During Period Value Stock Options and Restricted Stock Units Exercised and Employee Stock Purchase Plan Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units and shares of Common Stock under the ESPP Stock Issued During Period, Value, Conversion of Convertible Securities Issuance of shares of Common Stock upon conversion of Convertible Senior Notes Stock Issued During Period, Value, Issued for Services Issuance of shares of Common Stock for services rendered Stock Issued During Period, Value, New Issues Issuance of shares of Common Stock Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock compensation Amount of increase (decrease) in retained earnings due to the adjustment of prepaid tax assets from adoption of new accounting standard. Adoption of Accounting Standard Adjustment To Retained Earnings Adoption of ASU No. 2016-01 (Note 1) Number of share options (or share units) and restricted stock units exercised during the current period. Stock Issued During Period Shares Stock Options and Restricted Stock Units Exercised Issuance of shares of Common Stock upon exercise of stock options and restricted stock units Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of shares of Common Stock under the ESPP Number of shares issued Stock Issued During Period, Shares, Conversion of Convertible Securities Issuance of shares of Common Stock upon conversion of convertible senior notes Common stock issued in exchange of notes (in shares) Stock Issued During Period, Shares, Issued for Services Issuance of shares of Common Stock for services rendered Stock Issued During Period, Shares, New Issues Issuance of shares of Common Stock Public issuance of common stock CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Cash flows from operating activities: Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net income (loss) Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: Depreciation, Depletion and Amortization Depreciation and amortization Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill) Write-off of the acquired IPR&D In-process research and development impairment Share-based Compensation Stock-based compensation Deferred income taxes Deferred income taxes Other Noncash Income (Expense) Other, net Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Inventories Inventory Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued and other liabilities Increase or decrease in the carrying amount of the revenue or income not otherwise specified in the taxonomy which is expected to be taken into income within one year or the normal operating cycle, if longer. Increase (Decrease) Deferred Revenue Collaborative Agreements Deferred revenue-collaborative agreements Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Cash flows from investing activities: Payments to Acquire Businesses, Net of Cash Acquired Acquisition of business, net of cash acquired Payments for (Proceeds from) Investments Purchase of long term investments Payments to Acquire Productive Assets Capital expenditures Payments to Acquire Marketable Securities Purchases of marketable securities Proceeds from Sale and Maturity of Marketable Securities Sale and maturities of marketable securities Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Cash flows from financing activities: Proceeds from Stock Plans Proceeds from issuance of common stock under stock plans Proceeds from Issuance of Common Stock Net proceeds from sale of stock Proceeds from issuance of common stock, net Represents the amount paid in connection with senior not conversions. Payment In Connection Of Conversion Of Convertible Debt Cash paid in connection with senior note conversions Repayments of Debt and Capital Lease Obligations Direct financing arrangements repayments The cash outflow with regard to the contingent consideration during the period. Payment of Contingent Consideration Payment of contingent consideration Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Foreign currency translation change Effect of exchange rates on cash, cash equivalents, restricted cash and investments Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase in cash, cash equivalents, restricted cash and investments Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents, restricted cash and investments at end of period Cash, cash equivalents, restricted cash and investments at beginning of period Supplemental Cash Flow Information [Abstract] Supplemental Schedule of Cash Flow Information Interest Paid, Net Interest paid Income Taxes Paid, Net Income taxes paid Debt Conversion, Converted Instrument, Amount Reclassification to common stock and additional paid in capital in connection with conversions or exchange of convertible senior notes Capital Expenditures Incurred but Not yet Paid Unpaid purchases of property and equipment Debt Instrument, Interest Rate, Stated Percentage Interest rate of debt (as a percent) Organization and Summary of Significant Accounting Policies Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block] Organization and Summary of Significant Accounting Policies Revenues Revenue from Contract with Customer [Text Block] Revenues Business Combination Business Combination Disclosure [Text Block] Business Combination Marketable Securities Marketable Securities [Table Text Block] Marketable Securities Concentrations of Credit Risk Concentration Risk Disclosure [Text Block] Concentrations of Credit Risk Inventory Inventory Disclosure [Text Block] Inventory License Agreements This element may be used to describe all significant license agreements of the reporting entity. License Agreements [Text Block] License Agreements Property and Equipment Property, Plant and Equipment Disclosure [Text Block] Property and Equipment Intangible Assets and Goodwill Goodwill and Intangible Assets Disclosure [Text Block] Intangible Assets and Goodwill Accrued and Other Current Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued and Other Current Liabilities Convertible Notes Debt Disclosure [Text Block] Convertible Notes Stockholders’ Equity Stockholders' Equity Note Disclosure [Text Block] Stockholders’ Equity Stock Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock Compensation Income Taxes Income Tax Disclosure [Text Block] Income Taxes Net Income (Loss) Per Share Earnings Per Share [Text Block] Net Income (Loss) Per Share Employee Benefit Plans Pension and Other Postretirement Benefits Disclosure [Text Block] Employee Benefit Plans Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Segment Information Segment Reporting Disclosure [Text Block] Segment Information Interim Consolidated Financial Information (Unaudited) Quarterly Financial Information [Text Block] Interim Consolidated Financial Information (Unaudited) Consolidation, Policy [Policy Text Block] Principles of Consolidation Business Combinations Policy [Policy Text Block] Acquisitions