February 12, 1999

SECURITIES AND EXCHANGE COMMISSION
450 Fifth Street, NW
Judiciary Plaza
Washington, D.C.  20549

Re:  Schedule 13G-  Incyte Pharmaceuticals Inc.

Dear Sir or Madam:

We are hereby transmitting by EDGAR Schedule 13G on behalf of Waddell & Reed
Financial, Inc.

If you have any questions concerning the Schedule 13G filing, please call me at
(913) 236-1923.

Very truly yours,



Kristen A. Richards
Staff Attorney

KAR/fr


                                 UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C.  20549

                                  SCHEDULE 13G

                   Under the Securities Exchange Act of 1934

                          Incyte Pharmaceuticals Inc.
                                (Name of Issuer)

                                  Common Stock
                         (Title of Class of Securities)

                                   45337C102
                                 (CUSIP Number)

                               December 31, 1998
            (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
                                   is filed:

                               [ X] Rule 13d-1(b)
                               [ ] Rule 13d-1(c)
                               [ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).


CUSIP No. 45337C102      13G

1.   NAME OF REPORTING PERSON (S.S. or I.R.S. Identification No. of Above
Person)

     Waddell & Reed Investment Management Company  Tax ID No. 48-1106973

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:

     (a)  [ ]
     (b)  [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION:  Kansas

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

     5.   SOLE VOTING POWER             2,139,000  (See Item 4)

     6.   SHARED VOTING POWER      0

     7.   SOLE DISPOSITIVE POWER        2,139,000  (See Item 4)

     8.   SHARED DISPOSITIVE POWER      0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
     2,139,000  (See Item 4)

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN SHARES:  [ ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9:  7.7%

12.  TYPE OF PERSON REPORTING: IA


CUSIP No. 45337C102      13G

1.   NAME OF REPORTING PERSON (S.S. or I.R.S. Identification No. of Above
Person)

     Waddell & Reed, Inc.  Tax ID No. 43-1235675

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:

     (a)  [ ]
     (b)  [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION: Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

     5.   SOLE VOTING POWER             2,139,000  (See Item 4)

     6.   SHARED VOTING POWER      0

     7.   SOLE DISPOSITIVE POWER        2,139,000  (See Item 4)

     8.   SHARED DISPOSITIVE POWER      0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
     2,139,000  (See Item 4)

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN SHARES:  [ ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9:  7.7%

12.  TYPE OF PERSON REPORTING:  BD


CUSIP No. 45337C102      13G

1.   NAME OF REPORTING PERSON (S.S. or I.R.S. Identification No. of Above
Person)

     Waddell & Reed Financial Services, Inc.  Tax ID No. 43-1414157

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:

     (a)  [ ]
     (b)  [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION:  Missouri

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

     5.   SOLE VOTING POWER             2,139,000  (See Item 4)

     6.   SHARED VOTING POWER      0

     7.   SOLE DISPOSITIVE POWER        2,139,000  (See Item 4)

     8.   SHARED DISPOSITIVE POWER      0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
     2,139,000  (See Item 4)

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN SHARES:  [ ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9:  7.7%

12.  TYPE OF PERSON REPORTING: HC


CUSIP No. 45337C102      13G

1.   NAME OF REPORTING PERSON (S.S. or I.R.S. Identification No. of Above
Person)

     Waddell & Reed Financial, Inc.  Tax ID No. 51-0261715

2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP:

     (a)  [ ]
     (b)  [ ]

3.   SEC USE ONLY

4.   CITIZENSHIP OR PLACE OF ORGANIZATION:  Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

     5.   SOLE VOTING POWER             2,139,000  (See Item 4)

     6.   SHARED VOTING POWER      0

     7.   SOLE DISPOSITIVE POWER        2,139,000  (See Item 4)

     8.   SHARED DISPOSITIVE POWER      0

9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON:
     2,139,000  (See Item 4)

10.  CHECK IF THE AGGREGATE AMOUNT IN ROW 9 EXCLUDES CERTAIN SHARES:  [ ]

11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9:  7.7%

12.  TYPE OF PERSON REPORTING:  HC

Item 1(a):     Name of Issuer:  Incyte Pharmaceuticals Inc.

Item 1(b):     Address of Issuer's Principal Executive Offices:

          3174 Porter Drive
          Palo Alto, CA 94304

Item 2(a):     Name of Person Filing:

          (i)  Waddell & Reed Financial, Inc.
          (ii) Waddell & Reed Financial Services, Inc.
          (iii)     Waddell & Reed, Inc.
          (iv) Waddell & Reed Investment Management Company

Item 2(b):     Address of Principal Business Office:

          (i)-(iv):      6300 Lamar Avenue
                    P.O. Box 29217
                    Shawnee Mission, KS  66201-9217

Item 2(c):     Citizenship:

          (i), (iii): Delaware
          (ii):  Missouri
          (iv):  Kansas

Item 2(d):     Title of Class of Securities:  Common Stock

Item 2(e):     CUSIP Number:  45337C102

Item 3:   The reporting person is:

          (i)  Waddell & Reed Financial, Inc., a parent holding company in
               accordance with Reg. 240.13d-1(b)(1)(ii)(G);
          (ii) Waddell & Reed Financial Services, Inc., a parent holding company
               in accordance with Reg. 240.13d-1(b)(1)(ii)(G);
          (iii)Waddell & Reed, Inc., a broker-dealer in accordance with Reg.
               240.13d-1(b)(1)(ii)(A); and
          (iv) Waddell & Reed Investment Management Company, an investment
               advisor in accordance with Reg. 240.13d-1(b)(1)(ii)(E).

Item 4:   Ownership

          The securities reported on herein are beneficially owned by one or
more open-end investment companies or other managed accounts which are advised
or sub-advised by Waddell & Reed Investment Management Company ("WRIMCO"), an
investment advisory subsidiary of Waddell & Reed, Inc. ("WRI").  WRI is a
broker-dealer and underwriting subsidiary of Waddell & Reed Financial Services,
Inc., a parent holding company ("WRFSI").  In turn, WRFSI is a subsidiary of
Waddell & Reed Financial, Inc., a publicly traded company ("WDR").  The
investment advisory contract grants WRIMCO all investment and/or voting power
over securities owned by such advisory clients.  The investment sub-advisory
contracts grant WRIMCO investment power over securities owned by such sub-
advisory clients and, in most cases, voting power.  Any investment restriction
of a sub-advisory contract does not restrict investment discretion or power in a
material manner.  Therefore, WRIMCO may be deemed be to the beneficial owner of
the securities covered by this statement under Rule 13d-3 of the Securities
Exchange Act of 1934 (the "1934 Act").

     WRIMCO, WRI, WRFSI and WDR are of the view that they are not acting as a
"group" for purposes of Section 13(d) under the 1934 Act and that they are not
otherwise required to attribute to each other the "beneficial ownership" of
securities held by any of them or by any persons or entities advised by WRIMCO.
"Beneficial ownership" is attributed to the parent companies solely because of
the parent company relationship to WRIMCO.

          (a)  Amount beneficially owned:  2,139,000

          (b)  Percent of class:  7.7%

          (c)  Number of shares as to which the person has:

               (i)  Sole voting power to vote or to direct the vote:

                         WDR:  0
                         WRFSI:  0
                         WRI:  0
                         WRIMCO:  2,139,000

               (ii) Shares power to vote or to direct the vote:  0

               (iii)Sole power to dispose or to direct the disposition of:  0

               (iv) Shared power to dispose or to direct the disposition of:

                         WDR:  0
                         WRFSI:  0
                         WRI:  0
                         WRIMCO:  2,139,000

Item 5:   Ownership of Five Percent or Less of a Class:

          If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more
than 5 percent of the class of securities, check the following:   [ ]

Item 6:   Ownership of More than Five Percent on Behalf of Another Person:

          The clients of WRIMCO, including investment companies registered under
the Investment Company Act of 1940 and other managed accounts, have the right to
receive dividends from as well as the proceeds from the sale of such securities.

Item 7:   Identification and Classification of the Subsidiary Which Acquired the
Security Being Reported on By the Parent Holding Company:

          See Attached Exhibit 2.

Item 8:   Identification and Classification of Members of the Group:

          Not Applicable.

Item 9:   Notice of Dissolution of Group:

          Not Applicable.


Item 10:  Certification:

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the
securities and were not acquired and are not held in connection with or as a
participant in any transaction having that purpose or effect.

                                   SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Dated:February 12, 1999


By:  /s/ Helge K. Lee              By:  /s/ Helge K. Lee
- ---------------------              ---------------------
Name:  Helge K. Lee                Name:  Helge K. Lee
Title:  Secretary                  Title:  Vice President


Waddell & Reed, Inc.               Waddell & Reed Investment Management Company

By:  /s/ Helge K. Lee              By:  /s/ Helge K. Lee
- ---------------------              ---------------------
Name:  Helge K. Lee                Name:  Helge K. Lee
Title:  Senior Vice President           Title:  Senior Vice President


                                 EXHIBIT INDEX

Exhibit
   No.         Description

    1          Joint Filing Agreement

    2     Identification and Classification of the Subsidiary Which Acquired the
          Security Being Reported on by the Parent Holding Company

    3     Power of Attorney


                                   EXHIBIT 1

                             JOINT FILING AGREEMENT

     Waddell & Reed Financial, Inc., Waddell & Reed Financial Services, Inc.,
Waddell & Reed, Inc., and Waddell & Reed Investment Management Company (the
"Filing Persons"), hereby agree to file jointly a Schedule 13G and any
amendments thereto relating to the aggregate ownership by each of the Filing
Persons of any voting equity security of a class which is registered pursuant to
Section 12 of the Securities Exchange Act of 1934, as amended, as required by
Rule 13d-1 and Rule 13d-2 promulgated under the Securities Exchange Act of 1934.
Each of the Filing Persons agrees that the information set forth in such
Schedule 13G and any amendments thereto with respect to such Filing Person will
be true, complete and correct as of the date of such Schedule 13G or such
amendment, to the best of such Filing Person's knowledge and belief, after
reasonable inquiry.  Each of the Filing Persons makes no representations as to
the accuracy or adequacy of the information set forth in the Schedule 13G or any
amendments thereto with respect to any other Filing Person.  Each of the Filing
Persons shall promptly notify the other Filing Persons if any of the information
set forth in the Schedule 13G or any amendments thereto shall become inaccurate
in any material respect or if said person learns of information that would
require an amendment to the Schedule 13G.

     IN WITNESS WHEREOF, the undersigned have set their hands this 12th day of
February, 1999.



Waddell & Reed Financial, Inc.          Waddell & Reed Financial Services, Inc.

By:  /s/ Helge K. Lee              By:  /s/ Helge K. Lee
- ---------------------              ---------------------
Name:  Helge K. Lee           Name:  Helge K. Lee
Title:  Secretary                  Title:  Vice President



Waddell & Reed, Inc.               Waddell & Reed Investment Management Company

By:  /s/ Helge K. Lee              By:  /s/ Helge K. Lee
- ---------------------              ---------------------
Name:  Helge K. Lee           Name:  Helge K. Lee
Title:  Senior Vice President      Title:  Senior Vice President


                                   EXHIBIT 2
Waddell & Reed Investment Management Company - Tax ID No. 48-1106973

Investment Advisor registered under Section 203 of the Investment Advisor's Act
of 1940


                                   EXHIBIT 3

                               POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS, THAT:

     The undersigned Waddell & Reed Financial, Inc., a corporation organized and
existing under the laws of the State of Delaware, constitutes and appoints Helge
K. Lee, Robert L. Hechler and Kristen A. Richards and each of them severally,
its true and lawful attorneys-in-fact on behalf of the corporation and in its,
place and stead, in any and all capacities, to execute any and all Schedules 13G
or 13D and any amendments thereto relating to ownership of any voting equity
security of a class which is registered pursuant to Section 12 of the Securities
Exchange act of 1934, as amended, as required by rules and regulations
promulgated under said Securities Exchange Act of 1934, and to file the same
with all documents required in connection therewith, with the Securities and
Exchange Commission, granting unto said attorneys-in-fact and agents, and each
of them, full power and authority to do and perform each and every act and thing
requisite and necessary to be done and hereby ratifying and confirming all said
attorneys-in-fact and agents or any of them or their substitute or substitutes,
may lawfully do or cause to be done by virtue hereof.

     IN WITNESS WHEREOF, the corporation has caused this power of attorney to be
executed in its corporate name by its Executive Vice President and its Secretary
corporate seal to be affixed hereto on February 12, 1999.

                                   Waddell & Reed Financial, Inc.

                                   By: /s/Robert L. Hechler
                                   ------------------------
                                   Name:  Robert L. Hechler
                                   Title:  Executive Vice President

Attest:   /s/ Helge K. Lee
          Secretary