As filed with the Securities and Exchange Commission on September 29, 1999
                                                      Registration No. 333-73125

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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549
                                 ---------------
                         POST-EFFECTIVE AMENDMENT NO. 1
                                       TO
                                    FORM S-3
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933
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                          INCYTE PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

              Delaware                                94-3136539

     (State or other jurisdiction of       (I.R.S. Employer Identification No.)
      incorporation or organization)

                                3160 Porter Drive
                           Palo Alto, California 94304
                                 (650) 855-0555
              (Address, including zip code, and telephone number,
       including area code, of registrant's principal executive offices)

                                ROY A. WHITFIELD
                             Chief Executive Officer
                          INCYTE PHARMACEUTICALS, INC.
                                3160 Porter Drive
                           Palo Alto, California 94304
                                 (650) 855-0555
            (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                                   Copies to:

                                 STANTON D. WONG
                                  BRIAN M. WONG
                          Pillsbury Madison & Sutro LLP
                                  P.O. Box 7880
                         San Francisco, California 94120

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TERMINATION OF REGISTRATION Incyte Pharmaceuticals, Inc. (the "Registrant") hereby removes and withdraws from registration 207,071 shares of Common Stock, $.001 par value, of the Registrant. The Shares were unsold at the termination of the offering covered by this Registration Statement.

SIGNATURES Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this Post-Effective Amendment No. 1 to be signed on its behalf by the undersigned, thereunto duly authorized in the City of Palo Alto, State of California, on September 29, 1999. INCYTE PHARMACEUTICALS, INC. By /s/ ROY A. WHITFIELD ----------------------------------- Roy A. Whitfield Chief Executive Officer and Director KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below constitutes and appoints Roy A. Whitfield, Randal W. Scott, and Elias Bendekgey agents, each with full power of substitution and resubstitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments, including post-effective amendments, to this Registration Statement, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that each of said attorneys-in-fact and agents or their substitute or substitutes may lawfully do or cause to be done by virtue hereof. Pursuant to the requirements of the Securities Act, this Post-Effective Amendment No. 1 to the Registration Statement has been signed below by the following persons in the capacities and on the dates indicated. Name Title Date ---- ----- ---- /s/ ROY A. WHITFIELD - ---------------------- Chief Executive Officer (Principal September 29, 1999 Roy A. Whitfield Executive Officer) and Director /s/ ELIAS BENDEKGEY - ---------------------- General Counsel and Interim Chief September 21, 1999 Elias Bendekgey Financial Officer /s/ TIMOTHY HENN - ---------------------- Controller (Principal Accounting September 21, 1999 Timothy Henn Officer)

* - ------------------------------- Chairman of the Board February 26, 1999 Jeffrey J. Collinson * - ------------------------------- Director February 26, 1999 Barry M. Bloom * - ------------------------------- Director February 26, 1999 Frederick B. Craves * - ------------------------------- Director February 26, 1999 Jon S. Saxe * - ------------------------------- Director February 26, 1999 Randal W. Scott * By: /s/ ROY A. WHITFIELD ----------------------------- Roy A. Whitfield Attorney-in-Fact