UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549




                                  SCHEDULE 13G
                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*




                          Incyte Pharmaceuticals, Inc.
- -------------------------------------------------------------------------------
                                (Name of Issuer)


                          Common Stock, $.001 par value
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                   45337C-10-2
- -------------------------------------------------------------------------------
                                 (CUSIP Number)
- -------------------------------------------------------------------------------

                                December 31, 1998
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|  Rule 13d-1(b)
|X|  Rule 13d-1(c)
|_|  Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).



Cusip No. 45337C-10-2                   13G
          -----------

- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four Partners
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)   |_|
                                                    (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             New York
- ------------ ------------------------------------------------------------------
                                      5      SOLE VOTING POWER

                                             1,324,600
           NUMBER OF
                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-

                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          1,324,600

                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-

- ------------ ------------------------------------------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      1,324,600

- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
             SHARES*
                                                                       |_|

- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      4.8%

- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      PN
- ------------ ------------------------------------------------------------------



                                       2


Cusip No. 45337C-10-2
          -----------                      13G

- ------------ ------------------------------------------------------------------
     1       NAME OF REPORTING PERSON
             I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY)

             Four-Fourteen Partners LLC
- ------------ ------------------------------------------------------------------
     2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                    (a)   |_|
                                                    (b)   |_|

- ------------ ------------------------------------------------------------------
     3       SEC USE ONLY


- ------------ ------------------------------------------------------------------
     4       CITIZENSHIP OR PLACE OF ORGANIZATION

             Delaware
- ------------ ------------------------------------------------------------------

                                      5      SOLE VOTING POWER

                                             100,000
           NUMBER OF

                                  ---------- ----------------------------------
             SHARES                   6      SHARED VOTING POWER
          BENEFICIALLY
            OWNED BY                         -0-

                                  ---------- ----------------------------------
              EACH                    7      SOLE DISPOSITIVE POWER
           REPORTING
             PERSON                          100,000

                                  ---------- ----------------------------------
              WITH                    8      SHARED DISPOSITIVE POWER

                                             -0-


- ------------ ------------------------------------------------------------------
     9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                      100,000

- ------------ ------------------------------------------------------------------
    10       CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
             SHARES*
                                                                      |_|

- ------------ ------------------------------------------------------------------
    11       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

                      0.4%

- ------------ ------------------------------------------------------------------
    12       TYPE OF REPORTING PERSON*

                      OO
- ------------ ------------------------------------------------------------------


                                       3


Item 1.

              (a)   Name of Issuer

                    Incyte Pharmaceuticals, Inc. (the "Issuer")

              (b)   Address of Issuer's Principal Executive Offices

                    3174 Porter Drive
                    Palo Alto, CA 94304

Item 2.

              (a)   Name of Persons Filing

                    This Schedule 13G is being filed jointly by Four Partners
                    ("FP"), a New York general partnership, and Four-Fourteen
                    Partners LLC ("4-14P"), a Delaware limited liability
                    company.

                    The sole partners of FP are Andrew H. Tisch 1991 Trust,
                    for which Andrew H. Tisch is the managing trustee, Daniel R.
                    Tisch 1991 Trust, for which Daniel R. Tisch is the managing
                    trustee, James S. Tisch 1991 Trust, for which James S.
                    Tisch is the managing trustee, and Thomas J. Tisch 1991
                    Trust, for which Thomas J. Tisch is the managing trustee.
                    Thomas J. Tisch has been appointed the Manager of FP.
                    Andrew H. Tisch, Daniel R. Tisch, James S. Tisch and Thomas
                    J. Tisch are referred to herein as the "Messrs. Tisch."

                    The members of 4-14P are trusts for the benefit of the
                    offspring of the Messrs. Tisch, partnerships the partners
                    of which are such trusts and partnerships the partners of
                    which are such partnerships.  The Messrs. Tisch serve as the
                    trustees of such trusts.  Thomas J. Tisch has been appointed
                    the Manager of 4-14P.

              (b)   Address of Principal Business Office or, if none, Residence

                    The mailing address of FP and 4-14P is:

                    c/o Thomas J. Tisch
                    667 Madison Avenue
                    New York, NY 10021

              (c)   Citizenship

                    FP is a New York general partnership and 4-14P is a
                    Delaware limited liability company.

              (d)   Title of Class of Securities

                    Common Stock, $.001 par value (the "Shares")

              (e)   CUSIP Number

                    45337C-10-2

                                       4



Item 3.       If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b)
              or (c), check whether the person filing is a:

              (a)   |_| Broker or Dealer registered under Section 15 of the Act,

              (b)   |_| Bank as defined in section 3(a)(6) of the Act,

              (c)   |_| Insurance company as defined in section 3(a)(19) of the
              Act,

              (d)   |_| Investment company registered under section 8 of the
              Investment Company Act of 1940,

              (e)   |_| Investment Adviser registered under section 203 of the
               Investment Advisers Act of 1940,

              (f)   |_| An employee benefit plan, Pension Fund which is subject
              to the provisions of the Employee Retirement Income Security Act
              of 1974 or Endowment Fund; see (section) 240.13d-1(b)(1)(ii)(F),

              (g)   |_| A parent holding company, in accordance with (section)
              240.13d-1(b)(ii)(G) (Note:  See Item 7),

              (h)   |_| A savings association as defined in Section 3(b)
              of the Federal Deposit Insurance Act (12 U.S.C. 1813);

              (i)   |_| A church plan that is excluded from the definition of
              an investment company under section 3(c)(14) of the Investment
              Company Act of 1940 (15 U.S.C. 80a-3);

              (j)   |_| Group, in accordance with (section) 240.13d-1(b)(1)
              (ii)(J).

              If this statement is filed pursuant to (section) 240.13d-1(c),
              check this box         |X|.

Item 4.       Ownership

              (a)   Amount Beneficially Owned

                    As of the date hereof, FP is the beneficial owner
                    of 1,324,600 Shares and 4-14P is the beneficial owner of
                    100,000 Shares.  Collectively, FP and 4-14P own 1,424,600
                    Shares.

              (b)   Percent of Class

                    FP is the beneficial owner of 4.8% of the outstanding
                    Shares and 4-14P is the beneficial owner of 0.4% of the
                    outstanding Shares.  Collectively, FP and 4-14P own 5.2%
                    of the outstanding Shares.

              (c)   Number of shares as to which the person has:

                     (i)   Sole power to vote or to direct the vote

                           FP has directly the sole power to vote or to direct
                           the vote of the 1,324,600 Shares owned by it and
                           4-14P has directly


                                       5


                           the sole power to vote or to direct the vote of the
                           100,000 Shares owned by it.

                     (ii)  Shared power to vote or to direct the vote

                           By virtue of their status as managing trustees of
                           the trusts which are the general partners of FP and
                           as trustees of the trusts which are members of 4-14P,
                           partners of the partnerships that are members of
                           4-14P and partners of the partnerships that are
                           partners of the partnerships that are members of
                           4-14P, the Messrs. Tisch may be deemed to have
                           indirectly shared power to vote or direct the vote of
                           the 1,324,600 Shares owned by FP and the 100,000
                           Shares owned by 4-14P.

                     (iii) Sole power to dispose or to direct the disposition of

                           FP has directly the sole power to dispose or direct
                           the disposition of the 1,324,600 Shares owned by it
                           and 4-14P has directly the sole power to dispose or
                           direct the disposition of the 100,000 Shares owned
                           by it

                     (iv)  Shared power to dispose or to direct the disposition
                           of

                           By virtue of their status as managing trustees of
                           the trusts which are the general partners of FP and
                           as trustees of the trusts which are members of 4-14P,
                           partners of the partnerships that are members of
                           4-14P and partners of the partnerships that are
                           partners of the partnerships that are members of
                           4-14P, the Messrs. Tisch may be deemed to have
                           indirectly shared power to dispose or direct the
                           disposition of the 1,324,600 Shares owned by FP and
                           the 100,000 Shares owned by 4-14P.

Item 5.       Ownership of Five Percent or Less of a Class

              Not applicable.

Item 6.       Ownership of More than Five Percent on Behalf of Another Person

              Not applicable.

Item 7.       Identification and Classification of the Subsidiary Which Acquired
              the Security Being Reported on By the Parent Holding Company

              Not applicable.

Item 8.       Identification and Classification of Members of the Group

              Not applicable.

                                       6




Item 9.       Notice of Dissolution of Group

              Not applicable.

Item 10.      Certification

                    By signing below I certify that, to the best of my
              knowledge and belief, the securities referred to above were not
              acquired and are not held for the purpose of or with the effect of
              changing or influencing the control of the issuer of such
              securities and were not acquired and are not held in connection
              with or as a participant in any transaction having that purpose or
              effect.


                                       7



                                    SIGNATURE

          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Dated:   February 12, 1999

                                FOUR PARTNERS



                                By: /s/ Thomas J. Tisch
                                    ----------------------------------
                                    Thomas J. Tisch
                                    Manager of Four Partners


                                FOUR-FOURTEEN PARTNERS LLC



                                By: /s/ Thomas J. Tisch
                                    ------------------------------------
                                    Thomas J. Tisch
                                    Manager of Four-Fourteen Partners LLC



                                       8


                                                                        EXHIBIT
                                    AGREEMENT


          In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act
of 1934, as amended, the undersigned hereby agree that Amendment No. 1 to the
Schedule 13G dated February [  ], 1999 relating to the Common Stock, $.001 par
value, of Incyte Pharmaceuticals, Inc., as the same may be amended from time to
time hereafter, is being filed with the Securities and Exchange Commission on
behalf of each of them.

Dated:  February [  ], 1999

                                FOUR PARTNERS



                                By: /s/ Thomas J. Tisch
                                    ------------------------------------
                                    Thomas J. Tisch
                                    Manager of Four Partners


                                FOUR-FOURTEEN PARTNERS LLC



                                By: /s/ Thomas J. Tisch
                                    ------------------------------------
                                    Thomas J. Tisch
                                    Manager of Four-Fourteen Partners LLC



                                       9