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v3.26.3
Fair Value of Financial Instruments - Schedule of Assets Measured on a Recurring Basis (Details) - USD ($)
$ in Thousands
Sep. 30, 2026
Dec. 31, 2025
Fair value of financial instruments    
Long term equity investments $ 91,162 $ 47,991 [1]
Fair Value, Recurring | Estimate of Fair Value Measurement    
Fair value of financial instruments    
Cash and cash equivalents 3,275,881 3,097,817
Debt securities (government) 578,691 482,787
Long term equity investments 91,162 47,991
Total assets 3,945,734 3,628,595
Quoted Prices in Active Markets for Identical Assets (Level 1) | Fair Value, Recurring    
Fair value of financial instruments    
Cash and cash equivalents 3,275,881 3,097,817
Debt securities (government) 0 0
Long term equity investments 51,162 47,991
Total assets 3,327,043 3,145,808
Significant Other Observable Inputs (Level 2) | Fair Value, Recurring    
Fair value of financial instruments    
Cash and cash equivalents 0 0
Debt securities (government) 578,691 482,787
Long term equity investments 0 0
Total assets 578,691 482,787
Significant Unobservable Inputs (Level 3) | Fair Value, Recurring    
Fair value of financial instruments    
Cash and cash equivalents 0 0
Debt securities (government) 0 0
Long term equity investments 40,000 0
Total assets $ 40,000 $ 0
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Fair Value of Financial Instruments - Schedule of Contractual Maturities of Our Available-For-Sale Debt Securities (Details)
$ in Thousands
Sep. 30, 2026
USD ($)
Fair Value Disclosures [Abstract]  
Total $ 578,691
Less than 1 Year 211,841
1-5 Years $ 366,850
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v3.26.3
Property and Equipment, net - Schedule of Property and Equipment, Net (Details) - USD ($)
$ in Thousands
Sep. 30, 2026
Dec. 31, 2025
Property and equipment, net    
Property and equipment, gross $ 1,115,809 $ 1,105,951
Less accumulated depreciation and amortization (414,708) (375,066)
Property and equipment, net 701,101 730,885 [1]
Office equipment    
Property and equipment, net    
Property and equipment, gross 24,820 24,411
Laboratory equipment    
Property and equipment, net    
Property and equipment, gross 261,132 258,003
Computer equipment    
Property and equipment, net    
Property and equipment, gross 171,392 152,156
Land    
Property and equipment, net    
Property and equipment, gross 10,977 11,273
Building and leasehold improvements    
Property and equipment, net    
Property and equipment, gross 598,336 610,027
Operating lease right-of-use assets    
Property and equipment, net    
Property and equipment, gross 15,309 19,596
Construction in progress    
Property and equipment, net    
Property and equipment, gross $ 33,843 $ 30,485
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Other Comprehensive Income (Loss)
 9 Months Ended
Sep. 30, 2026
Text Block [Abstract]  
Other Comprehensive Income (Loss)
Note 11. Other Comprehensive Income (Loss)
The following tables summarize the activity related to each component of accumulated other comprehensive income (loss) during the nine months ended September 30, 2026 and 2025:
(Amounts presented net of taxes)Foreign Currency Translation Gains (Loss)Net Unrealized Gains (Losses) on Marketable SecuritiesDefined Benefit Pension PlansAccumulated Other Comprehensive Income (Loss)
Balances at January 1, 2026$51,433 $1,994 $(27,965)$25,462 
Other comprehensive loss before reclassifications(3,780)(8,914)— (12,694)
Net amount reclassified from accumulated other comprehensive income— — 688 688 
Net other comprehensive (loss) income(3,780)(8,914)688 (12,006)
Balances at September 30, 2026$47,653 $(6,920)$(27,277)$13,456 
(Amounts presented net of taxes)Foreign Currency Translation GainsNet Unrealized Gains on Marketable SecuritiesDefined Benefit Pension PlansAccumulated Other Comprehensive Income (Loss)
Balances at January 1, 2025$26,457 $346 $(39,924)$(13,121)
Other comprehensive income before reclassifications24,661 1,342 — 26,003 
Net amount reclassified from accumulated other comprehensive income— — 1,673 1,673 
Net other comprehensive income24,661 1,342 1,673 27,676 
Balances at September 30, 2025$51,118 $1,688 $(38,251)$14,555 
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v3.26.3
Net (Loss) Income Per Share - Schedule of Antidilutive Securities (Details) - shares
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Share-Based Payment Arrangement        
Anti-dilutive securities        
Outstanding stock options and awards (in shares) 9,236,142 8,111,846 2,409,289 11,064,833
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Stock Compensation (Tables)
 9 Months Ended
Sep. 30, 2026
Share-Based Payment Arrangement [Abstract]  
Schedule of Valuation Assumptions Used for Valuation of Fair Value of Stock Compensation Granted
We utilized the Black-Scholes valuation model for estimating the fair value of the stock compensation granted, with the following weighted-average assumptions:
Employee Stock OptionsEmployee Stock Purchase Plan
For the Three Months EndedFor the Nine Months EndedFor the Three Months EndedFor the Nine Months Ended
September 30,September 30,
20262025202620252026202520262025
Average risk-free interest rates4.28 %3.99 %4.14 %4.13 %4.33 %3.83 %3.98 %4.03 %
Average expected life (in years)5.225.175.125.010.500.500.500.50
Volatility30 %29 %30 %29 %34 %32 %33 %35 %
Weighted-average fair value (in dollars)$40.64 $23.58 $38.45 $23.45 $23.45 $14.72 $22.54 $14.95 
Schedule of Option Activity Under the 2010 Stock Plan
Option activity under our 2010 Stock Plan and 2024 Inducement Plan was as follows:
Shares Subject to
Outstanding Options
SharesWeighted Average
Exercise Price
Balance at December 31, 202510,859,861$83.46 
Options granted1,267,479$112.59 
Options exercised(3,404,545)$83.34 
Options cancelled(331,207)$88.61 
Balance at September 30, 20268,391,588$87.70 
Schedule of RSU Award and PSU Activity Under the 2010 Stock Plan
RSU and PSU award activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:
Shares Subject to
Outstanding Awards
SharesGrant Date Value
Balance at December 31, 20259,275,450$66.86 
RSUs granted 2,411,809$114.56 
PSUs granted282,010$148.52 
Additional PSUs earned63,187$61.76 
RSUs released(2,638,862)$67.48 
PSUs released(301,881)$63.94 
RSUs cancelled (471,271)$71.69 
PSUs cancelled(24,288)$84.61 
Balance at September 30, 20268,596,154$82.49 
Schedule of Shares Available for Grant
The following table summarizes our shares available for grant under the 2010 Stock Plan and 2024 Inducement Plan. Each RSU and PSU grant reduces the available share pool by one share.
Shares Available
for Grant
Balance at December 31, 20259,059,040
Options, RSUs and PSUs granted and issuance of shares for services rendered(4,090,265)
Options, RSUs and PSUs cancelled826,766
Balance at September 30, 20265,795,541
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Stock Compensation - Schedule of RSU Award and PSU Activity Under the 2010 Stock Plan and 2024 Inducement Plan (Details)
 9 Months Ended
Sep. 30, 2026
$ / shares
shares
RSU and PSU Activity Shares  
Outstanding at the beginning of the period (in shares) | shares 9,275,450
Outstanding at the end of the period (in shares) | shares 8,596,154
RSU and PSU Grant Price  
Grant date value of shares outstanding at the beginning of the period (in USD per share) | $ / shares $ 66.86
Grant date value of shares at the end of the period (in USD per share) | $ / shares $ 82.49
Restricted Stock Units (RSUs)  
RSU and PSU Activity Shares  
Granted (in shares) | shares 2,411,809
Released (in shares) | shares (2,638,862)
Cancelled (in shares) | shares (471,271)
RSU and PSU Grant Price  
Granted (in USD per share) | $ / shares $ 114.56
Released (in USD per share) | $ / shares 67.48
Cancelled (in USD per share) | $ / shares $ 71.69
Performance Shares  
RSU and PSU Activity Shares  
Granted (in shares) | shares 282,010
Additional PSUs earned (in shares) | shares 63,187
Released (in shares) | shares (301,881)
Cancelled (in shares) | shares (24,288)
RSU and PSU Grant Price  
Granted (in USD per share) | $ / shares $ 148.52
Additional PSUs earned (in USD per share) | $ / shares 61.76
Released (in USD per share) | $ / shares 63.94
Cancelled (in USD per share) | $ / shares $ 84.61
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 9 Months Ended
Sep. 30, 2026
segment
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Number of reportable segments 1
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v3.26.3
Fair Value of Financial Instruments - Narrative (Details) - ARIAD
$ in Millions
 9 Months Ended 12 Months Ended
Jun. 01, 2016
Sep. 30, 2026
USD ($)
Dec. 31, 2025
USD ($)
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Contingent consideration earned during the period but not yet paid   $ 10.9 $ 12.1
Liability      
Fair value of financial instruments      
Projected cash flows period (in years) 18 years    
Liability | Measurement Input, Discount Rate      
Fair value of financial instruments      
Valuation input (as a percent) 0.10 0.10 0.10
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v3.26.3
Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Income Tax Disclosure [Abstract]        
(Loss) income before provision for income taxes $ (688,848) $ 482,308 $ 406,266 $ 1,274,510
Provision for income taxes $ 95,955 $ 58,139 $ 302,134 $ 287,139
Effective tax rate (13.90%) 12.10% 74.40% 22.50%
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v3.26.3
Summary of Significant Accounting Policies
 9 Months Ended
Sep. 30, 2026
Accounting Policies [Abstract]  
Summary of Significant Accounting Policies
Note 2. Summary of Significant Accounting Policies
Basis of presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. The condensed consolidated balance sheet as of September 30, 2026, the condensed consolidated statements of operations, comprehensive income (loss), and stockholders’ equity for the three and nine months ended September 30, 2026 and 2025, and the condensed consolidated statements of cash flows for the nine months ended September 30, 2026 and 2025, are unaudited, but include all adjustments, consisting only of normal recurring adjustments, which we consider necessary for a fair presentation of the financial position, operating results and cash flows for the periods presented. The condensed consolidated balance sheet at December 31, 2025 has been derived from our audited consolidated financial statements.
Although we believe that the disclosures in these financial statements are adequate to make the information presented not misleading, certain information and footnote information normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”).
Results for any interim period are not necessarily indicative of results for any future interim period or for the entire year. The accompanying financial statements should be read in conjunction with the financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2025.
Principles of Consolidation. The condensed consolidated financial statements include the accounts of Incyte Corporation and our wholly owned subsidiaries. All inter-company accounts, transactions, and profits have been eliminated in consolidation.
Use of Estimates. The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, we evaluate our estimates. We base our estimates on historical experience and various other assumptions that we believe to be reasonable under the circumstances, the results of which form our basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results could differ from those estimates.
Change in Accounting Principle
Effective July 1, 2026, we changed our inventory costing method for commercial product manufactured by third-party contract manufacturers from the specific identification method to the first-in, first-out (“FIFO”) method. Following the change, all inventories are accounted for under the FIFO method. We believe this change in accounting method is preferable as it (i) aligns accounting policies with the predominant inventory costing method used by industry peers, improving comparability for investors; (ii) is consistent with how we manage our business; and (iii) provides a single, uniform inventory costing methodology across all of our inventory. This change in accounting principle did not have a material effect on inventory or cost of sales for all periods presented; nor did it have a material impact on opening retained earnings. Therefore, prior comparative financial statements have not been restated.
Recent Accounting Pronouncements and Regulatory Updates
In November 2024, the Financial Accounting Standards Board (“FASB”) issued ASU No. 2024-03, “Disaggregation of Income Statement Expenses (DISE).” This new guidance applies to all public entities and requires disclosures about specific types of expenses included in the expense captions presented on the face of the income statement as well as disclosures about selling expenses. Public entities must adopt the new standard prospectively for fiscal years beginning after December 15, 2026, and interim reporting periods beginning after December 15, 2027. Early adoption and retrospective application are permitted. We are currently evaluating the impact ASU No. 2024-03 will have on our consolidated financial statements and related disclosures.
In July 2025, the FASB issued ASU No. 2025-05, “Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses for Accounts Receivable and Contract Assets.” This amended guidance applies to all entities and aims to simplify the estimation of expected credit losses for current accounts receivable and contract assets by providing a practical expedient for all companies. The amendments are effective for annual reporting periods beginning after December 15, 2025 and interim reporting periods within those annual periods. We formally adopted ASU 2025-05, effective January 1, 2026, and elected the practical expedient provided to all companies. This adoption and related practical expedient election did not have and is not expected to have a material impact on our consolidated financial statements and related disclosures.
In September 2025, the FASB issued ASU No. 2025-06, “Intangibles - Goodwill and Other - Internal-Use (Subtopic 350-40): Targeted Improvements to the Accounting for Internal-Use Software.” This amended guidance applies to all entities and serves to modernize the accounting for software costs that are accounted for under Subtopic 350-40, Intangibles - Goodwill and Other - Internal-Use Software (referred to as “internal-use software”). The amendments in this update are effective for all entities for annual reporting periods beginning after December 15, 2027, and interim reporting periods within those annual reporting periods. Early adoption is permitted as of the beginning of an annual reporting period. Entities may adopt the new guidance using a prospective, modified, or retrospective transition approach. We are currently evaluating the impact ASU No. 2025-06 will have on our consolidated financial statements and related disclosures.
In September 2025, the FASB issued ASU No. 2025-07, “Derivatives and Hedging (Topic 815) and Revenue from Contracts with Customers (Topic 606): Derivatives Scope Refinements and Scope Clarification for Share-Based Noncash Consideration from a Customer in a Revenue Contract.” This amended guidance applies to all entities and refines the scope of derivative accounting and clarifies rules for share-based noncash consideration in revenue contracts. Specifically, this update is intended to address concerns about the application of derivative accounting to contracts that have features based on the operations or activities of one of the parties to the contract and to reduce diversity in the accounting for share-based payments in revenue contracts. The amendments in this update are effective for all entities for annual reporting periods beginning after December 15, 2026, and interim reporting periods within those annual reporting periods. Early adoption is permitted. Entities may adopt the new guidance prospectively, or on a modified retrospective basis. We are currently evaluating the impact ASU No. 2025-07 will have on our consolidated financial statements and related disclosures.
In December 2025, the FASB issued ASU No. 2025-10, “Government Grants (Topic 832): Accounting for Government Grants Received by Business Entities.” This accounting standard update establishes specific rules for the recognition, measurement, and presentation of government grants received by business entities. For public business entities, this amended guidance is applicable for fiscal years beginning after December 15, 2028, including interim periods within those fiscal years. Early adoption is permitted. Entities may adopt the new guidance using a modified prospective, modified retrospective, or full retrospective approach. We are currently evaluating the impact ASU No. 2025-10 will have on our consolidated financial statements and related disclosures.
In December 2025, the FASB issued ASU No. 2025-11, “Interim Reporting (Topic 270): Narrow-Scope Improvements.” The amendments in this update aim to enhance the guidance in Topic 270, Interim Reporting, by improving the navigability of the required interim disclosures and clarifying when that guidance is applicable. The amendments also provide additional guidance on what disclosures should be provided in interim reporting periods. Lastly, this updated guidance incorporates a principle that requires entities to disclose significant events since the end of the last annual reporting period. The amendments in this update apply to all entities that provide interim financial statements and notes in accordance with U.S. GAAP. For public business entities, this amended guidance is effective for interim reporting periods within annual reporting periods beginning after December 15, 2027. Early adoption is permitted, and the amendments in this update can be applied either prospectively or retrospectively to any or all periods presented in the financial statements. We are currently evaluating the impact ASU No. 2025-11 will have on our future condensed consolidated financial statements and related disclosures.
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v3.26.3
Property and Equipment, net (Tables)
 9 Months Ended
Sep. 30, 2026
Property, Plant, and Equipment [Abstract]  
Schedule of Property and Equipment, Net
Property and equipment, net consists of the following (in thousands):
September 30,
2026		December 31,
2025
Office equipment$24,820 $24,411 
Laboratory equipment261,132 258,003 
Computer equipment171,392 152,156 
Land10,977 11,273 
Building and leasehold improvements598,336 610,027 
Operating lease right-of-use assets15,309 19,596 
Construction in progress33,843 30,485 
1,115,809 1,105,951 
Less accumulated depreciation and amortization(414,708)(375,066)
Property and equipment, net$701,101 $730,885 
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v3.26.3
Fair Value of Financial Instruments (Tables)
 9 Months Ended
Sep. 30, 2026
Fair Value Disclosures [Abstract]  
Schedule of Marketable Securities Portfolio
The following is a summary of our marketable securities portfolio for the periods presented (in thousands):
Amortized
Cost		Unrealized GainsUnrealized Losses
Fair Value
September 30, 2026
Debt securities (government)$585,611 $64 $(6,984)$578,691 
December 31, 2025
Debt securities (government)$480,793 $2,028 $(34)$482,787 
The table below summarizes the contractual maturities of our available-for-sale debt securities as of September 30, 2026 (in thousands):
TotalLess than 1 Year1-5 Years
Fair value of debt securities (government)$578,691 $211,841 $366,850 
Schedule of Fair Value of Assets Measured on Recurring Basis
The following fair value hierarchy table presents information about each major category of our financial assets measured at fair value on a recurring basis (in thousands):
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Assets
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
September 30, 2026
Cash and cash equivalents$3,275,881 $— $— $3,275,881 
Debt securities (government)— 578,691 — 578,691 
Long term equity investments (Note 8)
51,162 — 40,000 91,162 
Total assets$3,327,043 $578,691 $40,000 $3,945,734 
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Assets
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
December 31, 2025
Cash and cash equivalents$3,097,817 $— $— $3,097,817 
Debt securities (government)— 482,787 — 482,787 
Long term equity investments (Note 8)
47,991 — — 47,991 
Total assets$3,145,808 $482,787 $— $3,628,595 
Schedule of Fair Value of Liabilities Measured on Recurring Basis
The following fair value hierarchy table presents information about each major category of our financial liabilities measured at fair value on a recurring basis (in thousands):
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Liabilities
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
September 30, 2026
Acquisition-related contingent consideration$— $— $92,000 $92,000 
Total liabilities$— $— $92,000 $92,000 
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Liabilities
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
December 31, 2025
Acquisition-related contingent consideration$— $— $121,000 $121,000 
Total liabilities$— $— $121,000 $121,000 
Schedule of Roll Forward of Level 3 Liabilities
The following is a roll forward of our Level 3 liabilities (in thousands):
2026
Balance at January 1, $121,000 
Contingent consideration earned during the period but not yet paid(10,892)
Payments made during the period(21,331)
Change in fair value of contingent consideration3,223 
Balance at September 30,$92,000 
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v3.26.3
Stock Compensation
 9 Months Ended
Sep. 30, 2026
Share-Based Payment Arrangement [Abstract]  
Stock Compensation
Note 12. Stock Compensation
2010 Stock Incentive Plan. Under our Amended and Restated 2010 Stock Incentive Plan, as amended (the “2010 Stock Plan”), we may issue common stock to employees, non-employee directors, consultants, and scientific advisors. Awards under the 2010 Stock Plan include stock options, restricted stock units (“RSUs”) and performance shares (“PSUs”). A total of 74,953,475 shares of common stock are reserved for issuance pursuant to the 2010 Stock Plan.
2024 Inducement Stock Incentive Plan. Our Board of Directors has adopted the Incyte Corporation 2024 Inducement Stock Incentive Plan, as amended (the “2024 Inducement Plan”). In reliance on Nasdaq Marketplace Rule 5635(c)(4), stockholder approval was not obtained. A total of 2,000,000 shares of common stock are reserved for issuance pursuant to the 2024 Inducement Plan.
We recorded $69.8 million and $201.2 million of stock compensation expense on our condensed consolidated statements of operations for the three and nine months ended September 30, 2026, respectively. We recorded $61.6 million and $187.2 million of stock compensation expense on our condensed consolidated statements of operations for the three and nine months ended September 30, 2025, respectively. Stock compensation expense included within our condensed consolidated statements of operations included research and development expense of $43.5 million, $120.9 million, $39.7 million and $114.1 million for the three and nine months ended September 30, 2026 and 2025, respectively. Stock compensation expense included within our condensed consolidated statements of operations also included selling, general and administrative expense of $25.1 million, $77.3 million, $21.0 million and $70.5 million for the three and nine months ended September 30, 2026 and 2025, respectively. Stock compensation expense included within our condensed consolidated statements of operations also included cost of sales of $1.2 million, $3.0 million, $0.9 million and $2.6 million, respectively, for the three and nine months ended September 30, 2026 and 2025.
We utilized the Black-Scholes valuation model for estimating the fair value of the stock compensation granted, with the following weighted-average assumptions:
Employee Stock OptionsEmployee Stock Purchase Plan
For the Three Months EndedFor the Nine Months EndedFor the Three Months EndedFor the Nine Months Ended
September 30,September 30,
20262025202620252026202520262025
Average risk-free interest rates4.28 %3.99 %4.14 %4.13 %4.33 %3.83 %3.98 %4.03 %
Average expected life (in years)5.225.175.125.010.500.500.500.50
Volatility30 %29 %30 %29 %34 %32 %33 %35 %
Weighted-average fair value (in dollars)$40.64 $23.58 $38.45 $23.45 $23.45 $14.72 $22.54 $14.95 
The risk-free interest rate is derived from the U.S. Federal Reserve rate in effect at the time of grant. The expected life calculation is based on the observed and expected time to the exercise of options by our employees based on historical exercise patterns for similar type options. Expected volatility is based on the historical volatility of our common stock over the period commensurate with the expected life of the options. A dividend yield of zero is assumed based on the fact that we have never paid cash dividends and have no present intention to pay cash dividends. Nonemployee awards are measured on the grant date by estimating the fair value of the equity instruments to be issued using the expected term, similar to our employee awards.
Option activity under our 2010 Stock Plan and 2024 Inducement Plan was as follows:
Shares Subject to
Outstanding Options
SharesWeighted Average
Exercise Price
Balance at December 31, 202510,859,861$83.46 
Options granted1,267,479$112.59 
Options exercised(3,404,545)$83.34 
Options cancelled(331,207)$88.61 
Balance at September 30, 20268,391,588$87.70 
Our annual stock option grants generally have a 10-year term and vest over four years, with 25% vesting after one year and the remainder vesting in 36 equal monthly installments, subject to customary retirement provisions that may accelerate the requisite service period for expense recognition purposes.
RSU and PSU award activity under the 2010 Stock Plan and 2024 Inducement Plan was as follows:
Shares Subject to
Outstanding Awards
SharesGrant Date Value
Balance at December 31, 20259,275,450$66.86 
RSUs granted 2,411,809$114.56 
PSUs granted282,010$148.52 
Additional PSUs earned63,187$61.76 
RSUs released(2,638,862)$67.48 
PSUs released(301,881)$63.94 
RSUs cancelled (471,271)$71.69 
PSUs cancelled(24,288)$84.61 
Balance at September 30, 20268,596,154$82.49 
RSUs and PSUs are granted to our employees at the share price on the date of grant. Each RSU represents the right to acquire one share of our common stock. Each RSU granted in connection with our annual equity awards will vest 25% annually over four years, while each RSU granted as outstanding merit awards or as part of retention award programs will vest in a single installment at the end of four years, subject to customary retirement provisions that may accelerate the requisite service period for expense recognition purposes.
We grant PSUs with performance and/or service-based milestones with graded and/or cliff vesting over three to six years. The shares of our common stock into which each PSU may convert is subject to a multiplier based on the level at which the financial, developmental and market performance conditions are achieved over the service period. Compensation expense for PSUs with financial and developmental performance conditions is recorded over the estimated service period for each milestone when the performance conditions are deemed probable of achievement. For PSUs containing performance conditions which were not deemed probable of achievement, no stock compensation expense is recorded. Compensation expense for PSUs with market performance conditions is calculated using a Monte Carlo simulation model as of the date of grant and recorded over the requisite service period. For the three and nine months ended September 30, 2026, we recorded $6.4 million and $21.8 million, respectively, of stock compensation expense for PSUs on our condensed consolidated statements of operations. For the three and nine months ended September 30, 2025 we recorded $2.6 million and $12.6 million, respectively, of stock compensation expense for PSUs on our condensed consolidated statements of operations.
The following table summarizes our shares available for grant under the 2010 Stock Plan and 2024 Inducement Plan. Each RSU and PSU grant reduces the available share pool by one share.
Shares Available
for Grant
Balance at December 31, 20259,059,040
Options, RSUs and PSUs granted and issuance of shares for services rendered(4,090,265)
Options, RSUs and PSUs cancelled826,766
Balance at September 30, 20265,795,541
We estimate an annualized forfeiture rate for our options, RSUs and PSUs. Under the true-up provisions of the stock compensation guidance, we will record additional expense if the actual forfeiture rate is lower than we estimated, and will record a recovery of prior expense if the actual forfeiture is higher than we estimated.
Total compensation cost of options granted but not yet vested, as of September 30, 2026, was $43.0 million, which is expected to be recognized over the weighted average period of approximately 1.4 years. Total compensation cost of RSUs granted but not yet vested, as of September 30, 2026, was $330.2 million, which is expected to be recognized over the weighted average period of approximately 1.6 years. Total compensation cost of PSUs granted but not yet vested, as of September 30, 2026, was $57.6 million, which is expected to be recognized over the weighted average period of 2.2 years, should the underlying performance conditions be deemed probable of achievement.
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v3.26.3
Employee Benefit Plans - Narrative (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Retirement Benefits [Abstract]        
Defined contribution expense $ 6.4 $ 5.8 $ 19.1 $ 17.3
Current year expected contributions total $ 12.6   $ 12.6  
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v3.26.3
Collaborative and Other Relationships - MacroGenics (Details) - MacroGenics
$ in Millions
 9 Months Ended 108 Months Ended
Sep. 30, 2026
USD ($)
Sep. 30, 2026
USD ($)
Minimum    
License Agreements    
Royalty payments on future global net sales (as a percent) 15.00%  
Maximum    
License Agreements    
Royalty payments on future global net sales (as a percent) 24.00%  
Developmental and Regulatory Milestones    
License Agreements    
Milestone payment made under license agreement   $ 215.0
Development and Regulatory Milestones | Maximum    
License Agreements    
Additional milestone payments under the license agreement $ 210.0 210.0
Commercialization Milestones | Maximum    
License Agreements    
Additional milestone payments under the license agreement $ 330.0 $ 330.0
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v3.26.3
Commitments and Contingencies - Commitments (Details) - Revolving Credit Facility
 1 Months Ended
Aug. 31, 2021
USD ($)
Sep. 30, 2026
USD ($)
Dec. 31, 2025
USD ($)
Commitments      
Aggregate principal amount $ 500,000,000.0    
Increase in maximum revolving commitments $ 250,000,000.0    
Consolidated leverage ratio 0.25    
Long-term line of credit   $ 0 $ 0
Letters of credit outstanding, amount   $ 0 $ 0
Minimum      
Commitments      
Commitment fee (as percent) 0.15%    
Maximum      
Commitments      
Commitment fee (as percent) 0.225%    
Base Rate      
Commitments      
Debt instrument, variable rate floor (as percent) 1.00%    
Base Rate | Minimum      
Commitments      
Interest rate margin (as percent) 0.125%    
Base Rate | Maximum      
Commitments      
Interest rate margin (as percent) 0.875%    
Secured Overnight Financing Rate (SOFR)      
Commitments      
Debt instrument, variable rate floor (as percent) 0.00%    
Debt instrument, credit spread adjustment on variable rate (as percent) 0.10%    
Secured Overnight Financing Rate (SOFR) | Minimum      
Commitments      
Interest rate margin (as percent) 1.125%    
Secured Overnight Financing Rate (SOFR) | Maximum      
Commitments      
Interest rate margin (as percent) 1.875%    
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v3.26.3
Fair Value of Financial Instruments
 9 Months Ended
Sep. 30, 2026
Fair Value Disclosures [Abstract]  
Fair Value of Financial Instruments
Note 4. Fair Value of Financial Instruments
The following is a summary of our marketable securities portfolio for the periods presented (in thousands):
Amortized
Cost		Unrealized GainsUnrealized Losses
Fair Value
September 30, 2026
Debt securities (government)$585,611 $64 $(6,984)$578,691 
December 31, 2025
Debt securities (government)$480,793 $2,028 $(34)$482,787 
The table below summarizes the contractual maturities of our available-for-sale debt securities as of September 30, 2026 (in thousands):
TotalLess than 1 Year1-5 Years
Fair value of debt securities (government)$578,691 $211,841 $366,850 
Debt security assets were assessed for risk of expected credit losses. As of September 30, 2026 and December 31, 2025, the available-for-sale debt securities were held in U.S. government-backed securities and in Treasury bonds and were assessed on an individual security basis to have a de minimis risk of credit loss.
Fair Value Measurements
FASB accounting guidance defines fair value as the price that would be received to sell an asset or paid to transfer a liability (“the exit price”) in an orderly transaction between market participants at the measurement date. The standard outlines a valuation framework and creates a fair value hierarchy in order to increase the consistency and comparability of fair value measurements and the related disclosures. In determining fair value, we use quoted prices and observable inputs. Observable inputs are inputs that market participants would use in pricing the asset or liability based on market data obtained from sources independent of us. The fair value hierarchy is broken down into three levels based on the source of inputs as follows:
Level 1—Valuations based on unadjusted quoted prices in active markets for identical assets or liabilities.
Level 2—Valuations based on observable inputs and quoted prices in active markets for similar assets and liabilities.
Level 3—Valuations based on inputs that are unobservable and models that are significant to the overall fair value measurement.
Recurring Fair Value Measurements
Our marketable securities consist of investments in U.S. government debt securities that are classified as available-for-sale.
At September 30, 2026 and December 31, 2025, our Level 2 U.S. government debt securities were valued using readily available pricing sources which utilize market observable inputs, including the current interest rate and other characteristics for similar types of investments. Our long term equity investments classified as Level 1 were valued using their respective closing stock prices on The Nasdaq Stock Market. We did not experience any transfers of financial instruments between the fair value hierarchy levels during the three and nine months ended September 30, 2026.
The following fair value hierarchy table presents information about each major category of our financial assets measured at fair value on a recurring basis (in thousands):
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Assets
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
September 30, 2026
Cash and cash equivalents$3,275,881 $— $— $3,275,881 
Debt securities (government)— 578,691 — 578,691 
Long term equity investments (Note 8)
51,162 — 40,000 91,162 
Total assets$3,327,043 $578,691 $40,000 $3,945,734 
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Assets
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
December 31, 2025
Cash and cash equivalents$3,097,817 $— $— $3,097,817 
Debt securities (government)— 482,787 — 482,787 
Long term equity investments (Note 8)
47,991 — — 47,991 
Total assets$3,145,808 $482,787 $— $3,628,595 
The following fair value hierarchy table presents information about each major category of our financial liabilities measured at fair value on a recurring basis (in thousands):
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Liabilities
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
September 30, 2026
Acquisition-related contingent consideration$— $— $92,000 $92,000 
Total liabilities$— $— $92,000 $92,000 
Fair Value Measurement at Reporting Date Using:
Quoted Prices in
Active Markets for
Identical Liabilities
(Level 1)		Significant Other
Observable
Inputs
(Level 2)		Significant
Unobservable
Inputs
(Level 3)		Balance as of
December 31, 2025
Acquisition-related contingent consideration$— $— $121,000 $121,000 
Total liabilities$— $— $121,000 $121,000 
The following is a roll forward of our Level 3 liabilities (in thousands):
2026
Balance at January 1, $121,000 
Contingent consideration earned during the period but not yet paid(10,892)
Payments made during the period(21,331)
Change in fair value of contingent consideration3,223 
Balance at September 30,$92,000 
The initial fair value of the contingent consideration was determined on the date of acquisition, June 1, 2016, using an income approach based on projected future net sales of ICLUSIG in the European Union and other countries for the approved third line treatment over 18 years, and discounted to present value at a rate of 10%. The fair value of the contingent consideration is remeasured each reporting period, with changes in fair value recorded in the condensed consolidated statements of operations. The valuation inputs utilized to estimate the fair value of the contingent consideration as of September 30, 2026 and December 31, 2025 included a discount rate of 10%, updated projections of future net sales of ICLUSIG in the European Union and other countries for the approved third line treatment, and related applicable royalty rates. The change in fair value of the contingent consideration during the three and nine months ended September 30, 2026 was due primarily to updated projections of future net sales of ICLUSIG, including the impact from fluctuations in foreign currency exchange rates, and the passage of time.
We generally make payments to Takeda Pharmaceutical Company Limited quarterly based on the royalties earned in the previous quarter. As of September 30, 2026 and December 31, 2025, contingent consideration earned but not yet paid was $10.9 million and $12.1 million, respectively, and was included in accrued and other current liabilities.
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v3.26.3
Revenues (Tables)
 9 Months Ended
Sep. 30, 2026
Revenue from Contract with Customer [Abstract]  
Schedule of Disaggregated Revenue The following table presents our disaggregated revenue for the periods presented (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
JAKAFI net sales1
$826,501 $791,071 $2,400,915 $2,264,271 
OPZELURA net sales2
254,880 187,968 847,631 471,172 
ICLUSIG net sales33,527 37,582 103,384 99,855 
PEMAZYRE net sales21,179 22,741 67,140 63,373 
MINJUVI/MONJUVI net sales54,630 41,990 157,543 102,672 
NIKTIMVO net sales67,368 45,830 182,765 95,597 
ZYNYZ net sales58,328 22,674 149,668 34,604 
Total net sales1,316,413 1,149,856 3,909,046 3,131,544 
JAKAVI product royalty revenues132,458 125,645 362,204 327,504 
OLUMIANT product royalty revenues39,052 37,111 113,938 101,393 
TABRECTA product royalty revenues6,833 6,513 19,506 19,558 
Other product royalty revenues12,648 1,855 21,225 4,408 
Total product royalty revenues190,991 171,124 516,873 452,863 
Milestone and contract revenues49,800 45,000 78,000 50,000 
Total revenues$1,557,204 $1,365,980 $4,503,919 $3,634,407 
1 2026 JAKAFI net sales include JAKAFI and JAKAFI XR following the launch of JAKAFI XR in the second quarter of 2026.
2 OPZELURA net sales for the nine months ended September 30, 2026 include $246.0 million related to our agreement with CMS to resolve our litigation related to the application of Medicaid rebate rules to OPZELURA. Refer to Note 16 for further information.
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v3.26.3
CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Retained Earnings (Accumulated Deficit)
Beginning balance at Dec. 31, 2024 $ 3,447,628 $ 193 $ 4,533,437 $ (13,121) $ (1,072,881)
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock (6,215)   (6,215)    
Issuance of shares of Common Stock for services rendered 82   82    
Stock compensation 60,982   60,982    
Other comprehensive (loss) income 6,883     6,883  
Net income 158,203       158,203
Ending balance at Mar. 31, 2025 3,667,563 193 4,588,286 (6,238) (914,678)
Beginning balance at Dec. 31, 2024 3,447,628 193 4,533,437 (13,121) (1,072,881)
Increase (Decrease) in Stockholders' Equity          
Other comprehensive (loss) income 27,676        
Net income 987,371        
Ending balance at Sep. 30, 2025 4,651,194 196 4,721,953 14,555 (85,510)
Beginning balance at Mar. 31, 2025 3,667,563 193 4,588,286 (6,238) (914,678)
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units and performance shares, net of shares withheld for taxes and shares of Common Stock under the ESPP 13,973 1 13,972    
Issuance of shares of Common Stock for services rendered 82   82    
Stock compensation 64,609   64,609    
Other comprehensive (loss) income 19,677     19,677  
Net income 404,999       404,999
Ending balance at Jun. 30, 2025 4,170,903 194 4,666,949 13,439 (509,679)
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock (6,674) 2 (6,676)    
Issuance of shares of Common Stock for services rendered 82   82    
Stock compensation 61,598   61,598    
Other comprehensive (loss) income 1,116     1,116  
Net income 424,169       424,169
Ending balance at Sep. 30, 2025 4,651,194 196 4,721,953 14,555 (85,510)
Beginning balance at Dec. 31, 2025 5,167,478 [1] 198 4,928,049 25,462 213,769
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock 90,969 2 90,967    
Issuance of shares of Common Stock for services rendered 92   92    
Stock compensation 64,126   64,126    
Other comprehensive (loss) income (3,148)     (3,148)  
Net income 303,330       303,330
Ending balance at Mar. 31, 2026 5,622,847 200 5,083,234 22,314 517,099
Beginning balance at Dec. 31, 2025 5,167,478 [1] 198 4,928,049 25,462 213,769
Increase (Decrease) in Stockholders' Equity          
Other comprehensive (loss) income (12,006)        
Net income 104,132        
Ending balance at Sep. 30, 2026 5,642,937 204 5,311,376 13,456 317,901
Beginning balance at Mar. 31, 2026 5,622,847 200 5,083,234 22,314 517,099
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units and performance shares, net of shares withheld for taxes and shares of Common Stock under the ESPP 71,216 1 71,215    
Issuance of shares of Common Stock for services rendered 92   92    
Stock compensation 67,263   67,263    
Other comprehensive (loss) income (2,596)     (2,596)  
Net income 585,605       585,605
Ending balance at Jun. 30, 2026 6,344,427 201 5,221,804 19,718 1,102,704
Increase (Decrease) in Stockholders' Equity          
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock 19,690 3 19,687    
Issuance of shares of Common Stock for services rendered 92   92    
Stock compensation 69,793   69,793    
Other comprehensive (loss) income (6,262)     (6,262)  
Net income (784,803)       (784,803)
Ending balance at Sep. 30, 2026 $ 5,642,937 $ 204 $ 5,311,376 $ 13,456 $ 317,901
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Collaborative and Other Relationships - Genesis (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
 1 Months Ended 3 Months Ended 9 Months Ended
May 31, 2026
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Dec. 31, 2025
 [1]
License Agreements            
Research and development   $ 1,791,656 $ 506,584 $ 2,824,509 $ 1,438,780  
Prepaid expenses and other current assets   295,517   295,517   $ 317,831
Other assets, net   $ 87,672   $ 87,672   $ 18,166
Genesis Molecular AI            
License Agreements            
Payment to acquire license agreement $ 120,000          
Collaborative arrangement upfront payment 80,000          
Collaborative arrangement, term   5 years   5 years    
Research and development   $ 4,000   $ 6,700    
Prepaid expenses and other current assets   16,000   16,000    
Other assets, net   $ 57,300   $ 57,300    
Genesis Molecular AI | Development Milestones            
License Agreements            
Maximum aggregate milestone payments 135,000          
Genesis Molecular AI | Regulatory Milestone            
License Agreements            
Maximum aggregate milestone payments 475,000          
Genesis Molecular AI | Commercialization Milestones            
License Agreements            
Maximum aggregate milestone payments 550,000          
Genesis Molecular AI | Investment in Genesis            
License Agreements            
Equity investment $ 40,000          
Investment owned (in shares) 4.3          
Per share price (in USD per share) $ 9.332          
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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Other Comprehensive Income (Loss) (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward]                
Beginning balance $ 6,344,427 $ 5,622,847 $ 5,167,478 [1] $ 4,170,903 $ 3,667,563 $ 3,447,628 $ 5,167,478 [1] $ 3,447,628
Other comprehensive (loss) income before reclassifications             (12,694) 26,003
Net amount reclassified from accumulated other comprehensive income             688 1,673
Other comprehensive (loss) income (6,262) (2,596) (3,148) 1,116 19,677 6,883 (12,006) 27,676
Ending balance 5,642,937 6,344,427 5,622,847 4,651,194 4,170,903 3,667,563 5,642,937 4,651,194
Accumulated Other Comprehensive Income (Loss)                
AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward]                
Beginning balance 19,718 22,314 25,462 13,439 (6,238) (13,121) 25,462 (13,121)
Other comprehensive (loss) income (6,262) (2,596) (3,148) 1,116 19,677 6,883    
Ending balance 13,456 $ 19,718 22,314 14,555 $ 13,439 (6,238) 13,456 14,555
Foreign Currency Translation Gains (Loss)                
AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward]                
Beginning balance     51,433     26,457 51,433 26,457
Other comprehensive (loss) income before reclassifications             (3,780) 24,661
Net amount reclassified from accumulated other comprehensive income             0 0
Other comprehensive (loss) income             (3,780) 24,661
Ending balance 47,653     51,118     47,653 51,118
Net Unrealized Gains (Losses) on Marketable Securities                
AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward]                
Beginning balance     1,994     346 1,994 346
Other comprehensive (loss) income before reclassifications             (8,914) 1,342
Net amount reclassified from accumulated other comprehensive income             0 0
Other comprehensive (loss) income             (8,914) 1,342
Ending balance (6,920)     1,688     (6,920) 1,688
Defined Benefit Pension Plans                
AOCI Including Portion Attributable to Noncontrolling Interest, Net of Tax [Roll Forward]                
Beginning balance     $ (27,965)     $ (39,924) (27,965) (39,924)
Other comprehensive (loss) income before reclassifications             0 0
Net amount reclassified from accumulated other comprehensive income             688 1,673
Other comprehensive (loss) income             688 1,673
Ending balance $ (27,277)     $ (38,251)     $ (27,277) $ (38,251)
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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 9 Months Ended
Sep. 30, 2026
segment
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
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v3.26.3
Collaborative and Other Relationships - Syndax (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended 61 Months Ended
Sep. 30, 2021
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Dec. 31, 2025
License Agreements              
Long term equity investments   $ 91,162   $ 91,162   $ 91,162 $ 47,991 [1]
Research and development   1,791,656 $ 506,584 2,824,509 $ 1,438,780    
Cost of sales (including definite-lived intangible amortization)   $ 108,744 99,001 $ 318,224 250,955    
Investment in Syndax              
License Agreements              
Investment owned (in shares)   1,400,000   1,400,000   1,400,000  
Long term equity investments   $ 26,700   $ 26,700   $ 26,700 29,900
(Loss) gain on equity investments   (4,300) 8,600 (3,100) 3,100    
Syndax              
License Agreements              
Upfront payment under license agreement           129,500  
Research and development   4,800 $ 6,300 15,100 $ 16,300    
Syndax | Axatilimab - Development Activities              
License Agreements              
Accrued and other liabilities   1,400   1,400   1,400 2,400
Syndax | Development and Regulatory Milestones | Maximum              
License Agreements              
Additional milestone payments under the license agreement   207,500   207,500   207,500  
Syndax | Commercialization Milestones | Maximum              
License Agreements              
Additional milestone payments under the license agreement   $ 225,000   $ 225,000   225,000  
Syndax | Incyte              
License Agreements              
Funding of future development costs   55.00% 55.00% 55.00% 55.00%    
United States | Syndax              
License Agreements              
Profit share percentage from co-commercialization efforts   50.00% 50.00% 50.00% 50.00%    
Cost of sales (including definite-lived intangible amortization)   $ 20,300 $ 14,300 $ 54,900 $ 24,600    
United States | Syndax | Axatilimab - Commercialization Activities              
License Agreements              
Accrued and other liabilities   $ 29,500   $ 29,500   $ 29,500 $ 27,600
United States | Syndax | Syndax              
License Agreements              
Funding of future development costs 45.00%            
United States | Syndax | Incyte              
License Agreements              
Funding of future development costs 55.00%            
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Accrued and Other Current Liabilities
 9 Months Ended
Sep. 30, 2026
Payables and Accruals [Abstract]  
Accrued and Other Current Liabilities
Note 10. Accrued and Other Current Liabilities
Accrued and other current liabilities consisted of the following (in thousands):
September 30,
2026		December 31,
2025
Royalties$45,003$40,678
Clinical related costs163,316175,932
Sales allowances623,940642,468
Sales and marketing58,89271,248
Accrued taxes2,8764,755
Operating lease liabilities5,6505,697
Other current liabilities67,74190,723
Total accrued and other current liabilities$967,418$1,031,501
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v3.26.3
Acquisitions (Details) - Vega Therapeutics, Inc.
$ in Millions
Jul. 06, 2026
USD ($)
Asset Acquisition [Line Items]  
Payments for asset acquisitions $ 1,250.0
Asset acquisition, consideration transferred, transaction cost 16.7
Asset acquisition, consideration transferred 1,267.0
In-process research and development assets 1,232.0
Asset acquisition, assets acquired and liabilities assumed, net 35.3
Deferred tax asset 37.5
Potential future milestone obligation (up to) $ 750.0
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v3.26.3
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Revenues:        
Total revenues $ 1,557,204 $ 1,365,980 $ 4,503,919 $ 3,634,407
Costs, expenses and other:        
Cost of sales (including definite-lived intangible amortization) 108,744 99,001 318,224 250,955
Contract dispute settlement 0 0 0 (242,251)
Research and development 1,791,656 506,584 2,824,509 1,438,780
Selling, general and administrative 364,273 329,081 1,044,095 985,794
Asset impairment and related disposal costs 0 0 23,214 0
Loss (gain) on change in fair value of acquisition-related contingent consideration 892 (12,204) 3,223 22,129
Total costs, expenses and other 2,265,565 922,462 4,213,265 2,455,407
(Loss) income from operations (708,361) 443,518 290,654 1,179,000
Interest income 32,174 26,781 103,979 74,846
Interest expense (605) (592) (1,756) (1,846)
(Loss) gain on equity investments (13,225) 8,558 3,171 3,064
Other, net 1,169 4,043 10,218 19,446
(Loss) income before provision for income taxes (688,848) 482,308 406,266 1,274,510
Provision for income taxes 95,955 58,139 302,134 287,139
Net (loss) income $ (784,803) $ 424,169 $ 104,132 $ 987,371
Net (loss) income per share:        
Basic (in USD per share) $ (3.86) $ 2.17 $ 0.52 $ 5.08
Diluted (in USD per share) $ (3.86) $ 2.11 $ 0.50 $ 4.95
Shares used in computing net (loss) income per share:        
Basic (in shares) 203,246 195,670 200,989 194,459
Diluted (in shares) 203,246 201,429 208,762 199,405
Net sales        
Revenues:        
Total revenues $ 1,316,413 $ 1,149,856 $ 3,909,046 $ 3,131,544
Product royalty revenues        
Revenues:        
Total revenues 190,991 171,124 516,873 452,863
Milestone and contract revenues        
Revenues:        
Total revenues $ 49,800 $ 45,000 $ 78,000 $ 50,000
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v3.26.3
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Statement of Comprehensive Income [Abstract]        
Net (loss) income $ (784,803) $ 424,169 $ 104,132 $ 987,371
Other comprehensive (loss) income:        
Foreign currency translation (loss) gain (2,057) 156 (3,780) 24,661
Unrealized (loss) gain on marketable securities, net of tax (4,429) 375 (8,914) 1,342
Defined benefit pension gain, net of tax 224 585 688 1,673
Other comprehensive (loss) income (6,262) 1,116 (12,006) 27,676
Comprehensive (loss) income $ (791,065) $ 425,285 $ 92,126 $ 1,015,047
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Fair Value of Financial Instruments - Schedule of Level 3 Liabilities (Details) - Estimate of Fair Value Measurement
$ in Thousands
 9 Months Ended
Sep. 30, 2026
USD ($)
Roll forward of Level 3 liabilities  
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v3.26.3
Stock Compensation - Schedule of Option Activity Under the 2010 Stock Plan and 2024 Inducement Plan (Details) - Shares Subject to Outstanding Options
 9 Months Ended
Sep. 30, 2026
$ / shares
shares
Shares  
Outstanding at the beginning of the period (in shares) | shares 10,859,861
Options granted (in shares) | shares 1,267,479
Options exercised (in shares) | shares (3,404,545)
Options cancelled (in shares) | shares (331,207)
Outstanding at the end of the period (in shares) | shares 8,391,588
Weighted Average Exercise Price  
Weighted average price of options at the beginning of the period (in USD per share) | $ / shares $ 83.46
Options granted (in USD per share) | $ / shares 112.59
Options exercised (in USD per share) | $ / shares 83.34
Options cancelled (in USD per share) | $ / shares 88.61
Weighted average price of options at the end of the period (in USD per share) | $ / shares $ 87.70
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v3.26.3
Concentration of Credit Risk and Current Expected Credit Losses
 9 Months Ended
Sep. 30, 2026
Risks and Uncertainties [Abstract]  
Concentration of Credit Risk and Current Expected Credit Losses
Note 5. Concentration of Credit Risk and Current Expected Credit Losses
In November 2009, we entered into a Collaboration and License Agreement with Novartis Pharma AG (formerly known as Novartis Pharmaceutical International Ltd.) (“Novartis”). In December 2009, we entered into a License, Development and Commercialization Agreement with Eli Lilly and Company (“Lilly”). Novartis and Lilly comprised, in aggregate, 14% and 17% of the accounts receivable balance as of September 30, 2026 and December 31, 2025, respectively. For further information relating to these collaboration and license agreements, refer to Note 8.
The concentration of credit risk related to our JAKAFI and OPZELURA sales is as follows:
Percentage of Total Net
Sales for the
Three Months Ended		Percentage of Total Net
Sales for the
Nine Months Ended
September 30,September 30,
2026202520262025
Customer A10 %14 %11 %13 %
Customer B22 %20 %21 %21 %
Customer C18 %18 %19 %19 %
Customer D12 %10 %11 %10 %
Customer E11 %11 %10 %10 %
We are exposed to risks associated with extending credit to customers related to the sale of products. Customers A, B, C, D, and E comprised, in the aggregate, 59% and 59% of the accounts receivable balance as of September 30, 2026 and December 31, 2025, respectively. The concentration of credit risk relating to our other sales or accounts receivable is not significant.
We assessed our collaborative and customer receivable assets as of September 30, 2026 according to our accounting policy for applying reserves for expected credit losses, noting minimal history of uncollectible receivables and the continued perceived creditworthiness of our third-party sales relationships, upon which the expected credit losses were considered de minimis. As of September 30, 2026 and December 31, 2025, we had a de minimis amount of allowance for doubtful accounts.
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v3.26.3
Net (Loss) Income Per Share - Schedule of Net (Loss) Income Per Share (Details) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Basic Net Income (Loss) Per Share        
Basic net (loss) income $ (784,803) $ 424,169 $ 104,132 $ 987,371
Weighted average common shares outstanding (in shares) 203,246 195,670 200,989 194,459
Basic net (loss) income per share ( in USD per share) $ (3.86) $ 2.17 $ 0.52 $ 5.08
Diluted Net Income (Loss) Per Share        
Diluted net (loss) income $ (784,803) $ 424,169 $ 104,132 $ 987,371
Weighted average common shares outstanding (in shares) 203,246 195,670 200,989 194,459
Dilutive stock options and awards ( in shares) 0 5,759 7,773 4,946
Weighted average shares used to compute diluted net (loss) income per share ( in shares) 203,246 201,429 208,762 199,405
Diluted net (loss) income per share ( in USD per share) $ (3.86) $ 2.11 $ 0.50 $ 4.95
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CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) - shares
 3 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Statement of Stockholders' Equity [Abstract]            
Issuance of shares of Common Stock upon exercise of stock options and settlement of employee restricted stock units, net of shares withheld for taxes (in shares) 3,031,088 795,114 1,473,992 2,011,476 64,400 363,987
Issuance of shares of Common Stock for services rendered (in shares) 731 907 955 962 1,220 1,208
Issuance of shares of Common Stock under the ESPP (in shares)   202,281     261,762  
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Net (Loss) Income Per Share (Tables)
 9 Months Ended
Sep. 30, 2026
Earnings Per Share [Abstract]  
Schedule of Calculation of Net (Loss) Income Per Share
Net (loss) income per share was calculated as follows for the periods indicated below:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Basic net (loss) income$(784,803)$424,169 $104,132 $987,371 
Weighted average common shares outstanding203,246195,670200,989194,459
Basic net (loss) income per share$(3.86)$2.17 $0.52 $5.08 
Diluted net (loss) income$(784,803)$424,169 $104,132 $987,371 
Weighted average common shares outstanding203,246195,670200,989194,459
Dilutive stock options and awards05,7597,7734,946 
Weighted average shares used to compute diluted net (loss) income per share 203,246201,429208,762199,405
Diluted net (loss) income per share$(3.86)$2.11 $0.50 $4.95 
Schedule of Antidilutive Securities Excluded From the Diluted Net Computation of (Loss) Earnings Per Share The potential common shares that were excluded from the diluted net (loss) income per share computation are as follows:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Outstanding stock options and awards9,236,1428,111,8462,409,28911,064,833
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v3.26.3
Collaborative and Other Relationships
 9 Months Ended
Sep. 30, 2026
Collaborative and Other Relationships [Abstract]  
Collaborative and Other Relationships
Note 8. Collaborative and Other Relationships
Novartis
In November 2009, we entered into a Collaboration and License Agreement with Novartis. Under the terms of the agreement, Novartis received exclusive development and commercialization rights outside of the United States to our JAK inhibitor ruxolitinib and certain back-up compounds for hematologic and oncologic indications, including all hematological malignancies, solid tumors and myeloproliferative diseases. We retained exclusive development and commercialization rights to JAKAFI (ruxolitinib) in the United States and in certain other indications. Novartis also received worldwide exclusive development and commercialization rights to our MET inhibitor compound capmatinib and certain back-up compounds in all indications.
Under this agreement, each company is responsible for costs relating to the development and commercialization of ruxolitinib in its respective territories, with costs of collaborative studies shared equally. Novartis is also responsible for all costs relating to the development and commercialization of capmatinib.
We were initially eligible to receive up to $174.0 million for the achievement of development milestones, up to $495.0 million for the achievement of regulatory milestones and up to $500.0 million for the achievement of sales milestones. In addition, we were initially eligible to receive up to $75.0 million of additional potential development and regulatory milestones relating to graft-versus-host-disease (“GVHD”). Since the inception of the agreement through September 30, 2026, we have recognized and received, in the aggregate, $157.0 million for the achievement of development milestones, $345.0 million for the achievement of regulatory milestones, and $200.0 million for the achievement of sales milestones.
We are obligated to pay to Novartis tiered royalties in the low single-digits on future JAKAFI net sales within the United States. On May 11, 2025, we and Novartis entered into a settlement agreement (the “Settlement Agreement”) with respect to litigation initiated by Novartis relating to the duration of royalty payments owed by us to Novartis under the Collaboration and License Agreement. As of March 31, 2025, we had approximately $537.1 million of accrued royalties relating to the dispute with Novartis included in accrued and other current liabilities on our condensed consolidated balance sheet. Under the Settlement Agreement, we paid Novartis $280.0 million as the settlement of disputed royalties on net sales of JAKAFI in the United States through December 31, 2024, and agreed to reduce by 50% the royalty rate payable by us on future net sales of JAKAFI in the United States beginning January 1, 2025 for a period defined in the Settlement Agreement. The reduced royalty paid for the quarter ended March 31, 2025, was approximately $14.9 million. The difference of $242.2 million between the total accrued royalties and the total amount paid by us to Novartis as disclosed above was recorded in Contract dispute settlement on our condensed consolidated statement of operations for the nine months ended September 30, 2025.
During the three and nine months ended September 30, 2026, such royalties on net sales within the United States totaled $20.2 million and $56.3 million, respectively, and were reflected in cost of sales on the condensed consolidated statements of operations. During the three and nine months ended September 30, 2025, such royalties on net sales within the United States totaled $19.3 million and $67.8 million, respectively, and were reflected in cost of sales on the condensed consolidated statements of operations. At September 30, 2026 and December 31, 2025, approximately $20.2 million and $20.3 million, respectively, of accrued royalties were included in accrued and other current liabilities on the condensed consolidated balance sheets.
We also are eligible to receive tiered, double-digit royalties ranging from the upper-teens to the mid-twenties on future JAKAVI (the trade name used by Novartis for ruxolitinib sales outside of the United States) net sales outside of the United States, and tiered, worldwide royalties on TABRECTA net sales that range from 12% to 14%. Product royalty revenue related to Novartis’ net sales of JAKAVI outside of the United States for the three and nine months ended September 30, 2026, was $132.5 million and $362.2 million, respectively. Product royalty revenue related to Novartis’ net sales of JAKAVI outside of the United States for the three and nine months ended September 30, 2025, was $125.6 million and $327.5 million, respectively. Product royalty revenue related to Novartis’ net sales of TABRECTA worldwide for the three and nine months ended September 30, 2026, was $6.8 million and $19.5 million, respectively. Product royalty revenue related to Novartis’ net sales of TABRECTA worldwide for the three and nine months ended September 30, 2025, was $6.5 million and $19.6 million, respectively.
Lilly – Baricitinib
In December 2009, we entered into a License, Development and Commercialization Agreement with Lilly. Under the terms of the agreement, Lilly received exclusive worldwide development and commercialization rights to our JAK inhibitor baricitinib, and certain back-up compounds for inflammatory and autoimmune diseases.
Under this agreement, we were initially eligible to receive up to $150.0 million for the achievement of development milestones, up to $365.0 million for the achievement of regulatory milestones and up to $150.0 million for the achievement of sales milestones. In October 2025, the parties amended the agreement to enable Lilly to commercialize baricitinib for the treatment of Type 1 diabetes mellitus and to restructure the royalty obligations on net sales of baricitinib, certain developmental and regulatory milestones associated with baricitinib, and the marketing and sales support obligations of Lilly. Beginning in October 2025, we are now eligible to receive either a fixed royalty amount or tiered royalties based on defined levels of quarterly global net sales, with the tiered royalties up to a rate in the mid-teens. Since the inception of the agreement through September 30, 2026, we recognized and received, in aggregate, $149.0 million for the achievement of development milestones, $335.0 million for the achievement of regulatory milestones, $50.0 million for the achievement of sales milestones, and $100.0 million for the functional intellectual property transfer related to Type 1 diabetes mellitus.
Product royalty revenue related to Lilly net sales of OLUMIANT outside of the United States for the three and nine months ended September 30, 2026 was $39.1 million and $113.9 million, respectively. Product royalty revenue related to Lilly net sales of OLUMIANT outside of the United States for the three and nine months ended September 30, 2025 was $37.1 million and $101.4 million, respectively.
MacroGenics
In October 2017, we entered into a Global Collaboration and License Agreement with MacroGenics, Inc. (“MacroGenics”). Under this agreement, we received exclusive development and commercialization rights worldwide to MacroGenics’ INCMGA0012 (formerly MGA012), an investigational monoclonal antibody that inhibits PD-1. Except as set forth in the succeeding sentence, we have sole authority over and bear all costs and expenses in connection with the development and commercialization of INCMGA0012 in all indications, whether as a monotherapy or as part of a combination regimen. MacroGenics has retained the right to develop and commercialize, at its cost and expense, its pipeline assets in combination with INCMGA0012. In addition, MacroGenics has the right to manufacture a portion of both companies’ global clinical and commercial supply needs of INCMGA0012.
Since the inception of the agreement, inclusive of amendments to the agreement, through September 30, 2026, we have paid MacroGenics developmental and regulatory milestones totaling $215.0 million. After these amendments and subsequent payments, MacroGenics will be eligible to receive up to an additional $210.0 million in future contingent development and regulatory milestones, and up to $330.0 million in sales milestones as well as tiered royalties ranging from 15% to 24% of global net sales. In June 2025, MacroGenics sold certain of its rights to such future tiered royalties on and after June 30, 2025 to Sagard Healthcare Partners (Delaware) II LP.
Syndax
In September 2021, we entered into a Collaboration and License Agreement with Syndax Pharmaceuticals, Inc. (“Syndax”), covering the worldwide development and commercialization of SNDX-6352 (“axatilimab”). Under the terms of our agreement, we received exclusive commercialization rights to axatilimab outside of the United States and share commercialization rights in the United States with Syndax. We are responsible for leading the commercialization strategy and booking all revenue from sales of axatilimab globally. Incyte and Syndax share equally the profits and losses from the co-commercialization efforts in the United States. Sales of axatilimab outside the United States are subject to our royalty payment obligations to Syndax, as set forth below. We and Syndax have agreed to co-develop axatilimab and to share development costs associated with global and U.S.-specific clinical trials, with Incyte responsible for 55% of such costs and Syndax responsible for 45% of such costs. Each company is responsible for funding any independent development activities.
Inclusive of an upfront, non-refundable payment, since the inception of the agreement through September 30, 2026, we have made payments of $129.5 million to Syndax, which were previously recorded in research and development expense or in other intangible assets, as discussed above. Syndax is eligible to receive up to $207.5 million in future contingent development and regulatory milestones and up to $225.0 million in sales milestones as well as tiered royalties ranging in the mid-teens on net sales in Europe and Japan and low double digit percentage on net sales in the rest of the world outside of the United States. Syndax’s right to receive royalties in any particular country will expire upon the last to occur of (a) the expiration of patent rights in that particular country, (b) a specified period of time after the first post-marketing authorization sale of a licensed product comprising axatilimab in that country, and (c) the expiration of any regulatory exclusivity for that licensed product in that country.
As of September 30, 2026, we held an investment of approximately 1.4 million shares of Syndax common stock. The fair market value of our long term investment in Syndax as of September 30, 2026 and December 31, 2025 was $26.7 million and $29.9 million, respectively. For the three and nine months ended September 30, 2026, we recorded an unrealized loss of $4.3 million and $3.1 million, respectively, based on the change in fair value of Syndax’s common stock during the respective periods. For the three and nine months ended September 30, 2025, we recorded an unrealized gain of $8.6 million and $3.1 million, respectively, based on the change in fair value of Syndax’s common stock during the respective periods.
Research and development expenses for the three and nine months ended September 30, 2026, includes $4.8 million and $15.1 million, respectively, related to our 55% share of the co-development costs for axatilimab. Research and development expenses for the three and nine months ended September 30, 2025, includes $6.3 million and $16.3 million, respectively, related to our 55% share of the co-development costs for axatilimab. At September 30, 2026 and December 31, 2025, $1.4 million and $2.4 million, respectively, was included in accrued and other liabilities on the condensed consolidated balance sheet for amounts due to Syndax under the agreement.
In connection with the United States co-commercialization efforts, Syndax’s 50% share of profit for the three and nine months ended September 30, 2026 was $20.3 million and $54.9 million, respectively. Syndax’s 50% share of profit for the three and nine months ended September 30, 2025 was $14.3 million and $24.6 million, respectively, which is reflected in cost of sales on the condensed consolidated statement of operations. At September 30, 2026 and December 31, 2025, $29.5 million and $27.6 million, respectively, was included in accrued and other liability on the consolidated balance sheet for amounts due to Syndax related to United States co-commercialization activities.
Prelude
In November 2025, we entered into an exclusive purchase option agreement with Prelude Therapeutics Incorporated (“Prelude”). Under the terms of the agreement, we secured an exclusive option to acquire Prelude’s mutant selective JAK2V617F JH2 inhibitor program, including Prelude’s library of preclinical candidates. We paid Prelude a total of $60.0 million, comprised of an upfront payment of $35.0 million, plus a $25.0 million equity investment in Prelude. The $35.0 million upfront payment was recorded in research and development expense during the fourth quarter of 2025. We purchased 6.25 million shares of Prelude non-voting common stock at a price of $4.00 per share. Of this $25.0 million equity investment, approximately $17.1 million was expensed in research and development during the fourth quarter of 2025 as a premium above fair value of the stock purchase. The remaining $7.9 million is the initial fair value of our investment in Prelude. We are accounting for our shares held in Prelude at fair value whereby the investment is marked to market through earnings in each reporting period. Given our intent to hold the investment for the foreseeable future, we have classified the investment within long term investments on the accompanying condensed consolidated balance sheets. For the three and nine months ended September 30, 2026, we recorded an unrealized loss of $8.9 million and unrealized gain of $6.3 million, respectively based on the change in fair value of Prelude’s common stock during the period. The fair market value of our total long term investment in Prelude as of September 30, 2026 and December 31, 2025 was $24.4 million and $18.1 million, respectively.
Prelude expects to advance the JAK2V617F program to pre-defined milestones. We may elect to exercise our exclusive option during the option period to acquire the program and associated assets from Prelude for $100.0 million. In addition, if we exercise our option, Prelude would be eligible to receive up to $775.0 million in additional clinical and regulatory milestones, and single digit royalties on global net sales.
If we elect to not exercise our option to acquire the program, all JAK2V617F global program rights and interests would remain in the sole ownership and control of Prelude.
Genesis
In May 2026, we entered into a License, Research and Collaboration Agreement with Genesis Molecular AI, Inc. (“Genesis”), covering the building and deployment of artificial intelligence to accelerate the discovery of novel molecules for collaboration targets. Under the terms of the agreement, we will identify targets and Genesis will subsequently use the Genesis Exploration of Molecular Space artificial intelligence platform to identify molecular structures directed at each target. All preclinical costs related to the collaboration are subject to joint research plans. We will be responsible for leading the clinical development and global commercialization efforts.
Based on the terms of the agreement, we paid Genesis a total of $120.0 million, comprised of an upfront non-refundable payment of $80.0 million plus a $40.0 million equity investment in Genesis. In addition, Genesis is eligible to receive up to $135.0 million for the achievement of development milestones, up to $475.0 million for the achievement of regulatory milestones and up to $550.0 million for the achievement of sales milestones on the initial target programs.
The $80.0 million upfront payment was determined to be a prepayment for future research and development services and thus will be amortized over the five-year term of the agreement. Research and development expenses during the three and nine months ended September 30, 2026, includes $4.0 million and $6.7 million, respectively, relating to the amortization of this upfront payment. Additionally, as of September 30, 2026, $16.0 million and $57.3 million were recorded in prepaid expenses and other current assets and other assets, net, respectively, on the condensed consolidated balance sheet relating to this upfront payment.
We purchased approximately 4.3 million shares of Genesis Series B-3 Preferred Stock for $40.0 million, at a price of $9.332 per share. As there is no readily determinable fair value for the shares we hold in Genesis, we have elected to account for our investment using the measurement alternative under ASC 321 whereby our investment is measured at cost, less any impairment, and adjusted for observable price changes in orderly transactions for identical or similar securities of Genesis. We monitor the investment for any observable price changes or impairment indicators. Any subsequent changes in fair value of our investment will be recognized within gain (loss) on equity investments on our condensed consolidated statements of operations. Given our intent to hold the investment for the foreseeable future, we have classified the investment within long term equity investments on the accompanying condensed consolidated balance sheets. For the three months ended September 30, 2026, we did not identify any impairment or observable price changes related to our investment in Genesis.
Other Agreements
In addition to the license and collaboration agreements discussed above, we have various other license and collaboration agreements that are not individually material to our operating results or financial condition at this time. Pursuant to the terms of those agreements, we may be required to pay, or we may receive, additional amounts contingent upon the occurrence of various future events such as future discovery, development, regulatory or commercial milestones, which in the aggregate could be material. In addition, if any products related to these collaborations are approved for sale, we may be required to pay, or we may receive, royalties on future sales. The payment or receipt of these amounts, however, is contingent upon the occurrence of various future events, the likelihood of which cannot presently be determined.
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v3.26.3
Concentration of Credit Risk and Current Expected Credit Losses - Narrative (Details) - Accounts Receivable - Credit Concentration Risk
 9 Months Ended 12 Months Ended
Sep. 30, 2026
Dec. 31, 2025
Novartis and Lilly    
Concentration of risk    
Percentage of concentration risk 14.00% 17.00%
Customer A, B, C, D, E    
Concentration of risk    
Percentage of concentration risk 59.00% 59.00%
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v3.26.3
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($)
$ in Thousands
Sep. 30, 2026
Dec. 31, 2025
 [1]
Current assets:    
Cash and cash equivalents $ 3,275,881 $ 3,097,817
Marketable securities—available-for-sale (amortized cost $585,611 and $480,793 as of September 30, 2026 and December 31, 2025, respectively; allowance for credit losses $0 as of September 30, 2026 and December 31, 2025) 578,691 482,787
Accounts receivable 1,237,027 1,024,407
Inventory 134,252 101,060
Prepaid expenses and other current assets 295,517 317,831
Total current assets 5,521,368 5,023,902
Restricted cash 1,760 1,852
Long term equity investments 91,162 47,991
Inventory 341,584 342,232
Property and equipment, net 701,101 730,885
Finance lease right-of-use assets, net 24,690 27,520
Other intangible assets, net 103,229 117,131
Goodwill 133,000 133,000
Deferred income tax asset 281,691 515,294
Other assets, net 87,672 18,166
Total assets 7,287,257 6,957,973
Current liabilities:    
Accounts payable 235,369 209,938
Accrued compensation 190,994 228,071
Accrued and other current liabilities 967,418 1,031,501
Finance lease liabilities 4,128 4,516
Acquisition-related contingent consideration 39,909 41,144
Total current liabilities 1,437,818 1,515,170
Acquisition-related contingent consideration 52,091 79,856
Finance lease liabilities 27,634 30,199
Other liabilities 126,777 165,270
Total liabilities 1,644,320 1,790,495
Commitments and contingencies (Note 16)
Stockholders’ equity:    
Preferred Stock, $0.001 par value; 5,000,000 shares authorized; none issued or outstanding 0 0
Common Stock, $0.001 par value; 400,000,000 shares authorized; 204,002,500 and 198,460,009 shares issued and outstanding as of September 30, 2026 and December 31, 2025, respectively 204 198
Additional paid-in capital 5,311,376 4,928,049
Accumulated other comprehensive income 13,456 25,462
Retained earnings 317,901 213,769
Total stockholders’ equity 5,642,937 5,167,478
Total liabilities and stockholders’ equity $ 7,287,257 $ 6,957,973
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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Stock Compensation - Schedule of Shares Available For Grant (Details)
 9 Months Ended
Sep. 30, 2026
shares
Share-Based Payment Arrangement [Abstract]  
Share-based compensation arrangement by share-based payment award, equity instruments other than options and stock appreciation rights, impact on authorized share limitation (in shares) 1
Shares Available for Grant  
Beginning Balance (in shares) 9,059,040
Options, RSUs and PSUs granted and issuance of shares for services rendered (in shares) (4,090,265)
Options, RSUs and PSUs cancelled (in shares) 826,766
Ending Balance (in shares) 5,795,541
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v3.26.3
Segment Reporting (Tables)
 9 Months Ended
Sep. 30, 2026
Segment Reporting [Abstract]  
Segment Reporting
Net (loss) income for our segment was as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Net sales$1,316,413 $1,149,856 $3,909,046 $3,131,544 
Product royalty revenues190,991 171,124 516,873 452,863 
Milestone and contract revenues49,800 45,000 78,000 50,000 
Total revenues1,557,204 1,365,980 4,503,919 3,634,407 
Costs, expenses and other:
Cost of sales (including definite-lived intangible amortization)108,744 99,001 318,224 250,955 
Contract dispute settlement— — — (242,251)
Research and development - internal1
283,647 250,140 812,438 715,171 
Research and development - external2
270,746 256,344 762,208 695,459 
Other research and development3
1,237,263 100 1,249,863 28,150 
Sales and marketing296,885 272,302 842,200 786,265 
General and administrative67,388 56,779 201,895 199,529 
Asset impairment and related disposal costs— — 23,214 — 
Loss (gain) on change in fair value of acquisition-related contingent consideration892 (12,204)3,223 22,129 
Other segment items4
76,442 19,349 186,522 191,629 
Net (loss) income$(784,803)$424,169 $104,132 $987,371 
1.Research and development - internal is comprised of internally generated costs such as salaries, travel, regulatory costs, lab costs and contracting.
2.Research and development - external is comprised of specific program spend with external vendors (i.e. contract manufacturing organizations, contract research organizations and lab vendors for clinical, technical operations and toxicology services).
3.Other research and development is comprised of all other costs including certain one-time costs resulting from the acquisition of IPR&D assets and one-time development milestone expenses.
4.Other segment items is comprised of interest income, interest expense, realized and unrealized gain (loss) on equity investments, other, net, and provision for income taxes.
Schedule of Revenue from External Customers by Geographic Areas
Total revenues by geographic region were as follows (in thousands):
Three Months Ended September 30,Nine Months Ended September 30,
2026202520262025
United States$1,434,977 $1,261,261 $4,166,555 $3,375,171 
Europe107,374 100,306 304,934 247,744 
Other countries14,853 4,413 32,430 11,492 
Total revenues$1,557,204 $1,365,980 $4,503,919 $3,634,407 
Schedule of Long-Lived Assets by Geographic Areas
Property and equipment, net by geographic location was as follows (in thousands):
September 30,
2026		December 31,
2025
United States$397,790 $406,829 
Switzerland291,013 309,802 
Other countries12,298 14,254 
Total property and equipment, net$701,101 $730,885 
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v3.26.3
Organization and Business
 9 Months Ended
Sep. 30, 2026
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Organization and Business
Note 1. Organization and Business
Incyte Corporation (including its subsidiaries, “Incyte,” “we,” “us,” or “our”) is a global biopharmaceutical company engaged in the discovery, development and commercialization of proprietary therapeutics. Our portfolio includes compounds in various stages, ranging from preclinical to late-stage development, and commercialized products JAKAFI®/JAKAFI XRTM (ruxolitinib), ICLUSIG® (ponatinib), PEMAZYRE® (pemigatinib), OPZELURA® (ruxolitinib cream), MINJUVI® (tafasitamab), MONJUVI® (tafasitamab-cxix) and ZYNYZ® (retifanlimab-dlwr), as well as NIKTIMVO™ (axatilimab-csfr), which is co-commercialized. Our operations are treated as one operating segment.
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v3.26.3
Insider Trading Arrangements
 3 Months Ended
Sep. 30, 2026
shares
Trading Arrangements, by Individual  
Non-Rule 10b5-1 Arrangement Adopted false
Non-Rule 10b5-1 Arrangement Terminated false
Steven Stein [Member]  
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement Steven Stein, our Executive Vice President, Chief Medical Officer and Head of Late-Stage Development, adopted a trading plan on August 7, 2026 providing for the sale of up to an aggregate of 282,480 shares of our common stock until August 7, 2027. On July 29, 2026, Dr. Stein terminated a trading plan which was previously adopted on March 16, 2026 and provided for the sale of up to an aggregate of 207,534 shares of our common stock until March 17, 2027. No sales were executed under the terminated trading plan.
Lee Heeson [Member]  
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
Lee Heeson, our Executive Vice President and Head of Incyte International, adopted a trading plan on August 14, 2026 providing for the sale of up to an aggregate of 10,694 shares of our common stock until August 17, 2027.
Name Lee Heeson
Title Executive Vice President and Head of Incyte International
Rule 10b5-1 Arrangement Adopted true
Adoption Date August 14, 2026
Expiration Date August 17, 2027
Arrangement Duration 368 days
Aggregate Available 10,694
Thomas Tray [Member]  
Trading Arrangements, by Individual  
Material Terms of Trading Arrangement
Thomas Tray, our Vice President, Finance and Chief Accounting Officer, adopted a trading plan on July 31, 2026 providing for the sale of up to an aggregate of 4,128 shares of our common stock until July 31, 2027.
Name Thomas Tray
Title Vice President, Finance and Chief Accounting Officer
Rule 10b5-1 Arrangement Adopted true
Adoption Date July 31, 2026
Expiration Date July 31, 2027
Arrangement Duration 365 days
Aggregate Available 4,128
Steven Stein, August 2026 Plan [Member] | Steven Stein [Member]  
Trading Arrangements, by Individual  
Name Steven Stein
Title Executive Vice President, Chief Medical Officer and Head of Late-Stage Development
Rule 10b5-1 Arrangement Adopted true
Adoption Date August 7, 2026
Expiration Date August 7, 2027
Arrangement Duration 365 days
Aggregate Available 282,480
Steven Stein, March 2026 Plan [Member] | Steven Stein [Member]  
Trading Arrangements, by Individual  
Name Steven Stein
Title Executive Vice President, Chief Medical Officer and Head of Late-Stage Development
Rule 10b5-1 Arrangement Terminated true
Termination Date July 29, 2026
Aggregate Available 207,534
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Fair Value of Financial Instruments - Schedule of Liabilities Measured on a Recurring Basis (Details) - Fair Value, Recurring - USD ($)
$ in Thousands
Sep. 30, 2026
Dec. 31, 2025
Estimate of Fair Value Measurement    
Fair value of financial instruments    
Acquisition-related contingent consideration $ 92,000 $ 121,000
Total liabilities 92,000 121,000
Quoted Prices in Active Markets for Identical Assets (Level 1)    
Fair value of financial instruments    
Acquisition-related contingent consideration 0 0
Total liabilities 0 0
Significant Other Observable Inputs (Level 2)    
Fair value of financial instruments    
Acquisition-related contingent consideration 0 0
Total liabilities 0 0
Significant Unobservable Inputs (Level 3)    
Fair value of financial instruments    
Acquisition-related contingent consideration 92,000 121,000
Total liabilities $ 92,000 $ 121,000
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Accrued and Other Current Liabilities (Tables)
 9 Months Ended
Sep. 30, 2026
Payables and Accruals [Abstract]  
Schedule of Accrued and Other Current Liabilities
Accrued and other current liabilities consisted of the following (in thousands):
September 30,
2026		December 31,
2025
Royalties$45,003$40,678
Clinical related costs163,316175,932
Sales allowances623,940642,468
Sales and marketing58,89271,248
Accrued taxes2,8764,755
Operating lease liabilities5,6505,697
Other current liabilities67,74190,723
Total accrued and other current liabilities$967,418$1,031,501
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Stock Compensation - Schedule of Valuation Assumptions Used for Value of Stock Compensation Granted (Details) - $ / shares
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Employee Stock Purchase Plan        
Weighted-average fair value assumptions        
Average risk-free interest rates 4.33% 3.83% 3.98% 4.03%
Average expected life (in years) 6 months 6 months 6 months 6 months
Volatility 34.00% 32.00% 33.00% 35.00%
Weighted-average fair value (in USD per share) $ 23.45 $ 14.72 $ 22.54 $ 14.95
Employee Stock Options        
Weighted-average fair value assumptions        
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Average expected life (in years) 5 years 2 months 19 days 5 years 2 months 1 day 5 years 1 month 13 days 5 years 3 days
Volatility 30.00% 29.00% 30.00% 29.00%
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v3.26.3
Property and Equipment, net
 9 Months Ended
Sep. 30, 2026
Property, Plant, and Equipment [Abstract]  
Property and Equipment, net
Note 9. Property and Equipment, net
Property and equipment, net consists of the following (in thousands):
September 30,
2026		December 31,
2025
Office equipment$24,820 $24,411 
Laboratory equipment261,132 258,003 
Computer equipment171,392 152,156 
Land10,977 11,273 
Building and leasehold improvements598,336 610,027 
Operating lease right-of-use assets15,309 19,596 
Construction in progress33,843 30,485 
1,115,809 1,105,951 
Less accumulated depreciation and amortization(414,708)(375,066)
Property and equipment, net$701,101 $730,885 
In May 2024, we purchased additional property in Wilmington, Delaware, including land, office buildings and parking garages for a purchase price of $48.7 million. Subsequent to the purchase, we incurred additional construction costs of approximately $28.6 million through December 2025. During December 2025, the downtown Wilmington, Delaware properties met the criteria to be classified as assets held for sale. As a result of this classification, we recorded an asset impairment charge of $76.3 million on our consolidated statement of operations for the year ended December 31, 2025 relating to the downtown Wilmington properties in order to reflect the properties at the lower of their carrying amount or estimated fair value less cost to sell as of December 31, 2025. The estimated fair value less cost to sell of the properties was recorded within the Prepaid expenses and other current assets line item on our consolidated balance sheet as of December 31, 2025. During the first quarter of 2026, we sold these downtown properties, and recognized an additional $23.2 million of expenses relating to disposal costs, which are included in Asset impairment and related disposal costs in the condensed consolidated statements of operations.
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Income Taxes - Narrative (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2026
Vega Therapeutics, Inc.    
Effective Income Tax Rate Reconciliation [Line Items]    
Non-deductible asset acquisition charges $ 1,230 $ 1,230
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v3.26.3
Net (Loss) Income Per Share
 9 Months Ended
Sep. 30, 2026
Earnings Per Share [Abstract]  
Net (Loss) Income Per Share
Note 14. Net (Loss) Income Per Share
Net (loss) income per share was calculated as follows for the periods indicated below:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Basic net (loss) income$(784,803)$424,169 $104,132 $987,371 
Weighted average common shares outstanding203,246195,670200,989194,459
Basic net (loss) income per share$(3.86)$2.17 $0.52 $5.08 
Diluted net (loss) income$(784,803)$424,169 $104,132 $987,371 
Weighted average common shares outstanding203,246195,670200,989194,459
Dilutive stock options and awards05,7597,7734,946 
Weighted average shares used to compute diluted net (loss) income per share 203,246201,429208,762199,405
Diluted net (loss) income per share$(3.86)$2.11 $0.50 $4.95 
All stock options and stock awards were excluded from the diluted share calculation for the three months ended September 30, 2026 because their effect would have been anti-dilutive, as we were in a net loss position. The potential common shares that were excluded from the diluted net (loss) income per share computation are as follows:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Outstanding stock options and awards9,236,1428,111,8462,409,28911,064,833
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v3.26.3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Cash flows from operating activities:    
Net income $ 104,132 $ 987,371
Adjustments to reconcile net income to net cash provided by operating activities:    
Depreciation and amortization 74,453 69,304
Stock-based compensation 201,182 187,189
Deferred income taxes 271,762 234,188
Other, net 23,092 3,445
Gain on equity investments (3,171) (3,064)
Loss on change in fair value of acquisition-related contingent consideration 3,223 22,129
Changes in operating assets and liabilities:    
Accounts receivable (212,687) (42,275)
Prepaid expenses and other assets (85,700) (221,275)
Inventory (45,772) (53,654)
Accounts payable 31,487 (26,414)
Accrued and other liabilities (160,310) (286,747)
Net cash provided by operating activities 201,691 870,197
Cash flows from investing activities:    
Purchase of long term investments (40,000) 0
Sale of equity investments 0 8
Capital expenditures (38,244) (36,990)
Payments for intangible assets (5,000) (25,000)
Purchases of marketable securities (246,787) (212,852)
Maturities of marketable securities 145,700 209,643
Net cash used in investing activities (184,331) (65,191)
Cash flows from financing activities:    
Excise tax paid on repurchase of Common Stock 0 (19,100)
Proceeds from issuance of Common Stock under stock plans 295,376 61,553
Tax withholdings related to restricted stock unit and performance share vesting (113,501) (60,469)
Payment of finance lease liabilities (3,491) (3,386)
Payment of contingent consideration (14,168) (15,298)
Net cash provided by (used in) financing activities 164,216 (36,700)
Effect of exchange rates on cash, cash equivalents, and restricted cash (3,604) (908)
Net increase in cash, cash equivalents, and restricted cash 177,972 767,398
Cash, cash equivalents, and restricted cash at beginning of period 3,099,669 1,689,451
Cash, cash equivalents, and restricted cash at end of period 3,277,641 2,456,849
Supplemental Schedule of Cash Flow Information    
Income taxes paid 18,310 185,221
Cash paid for contract dispute settlement 0 294,881
Unpaid purchase of intangible asset 7,000 0
Unpaid purchases of property and equipment 651 4,158
Leased assets obtained in exchange for new operating lease liabilities 572 3,163
Leased assets obtained in exchange for new finance lease liabilities $ 505 $ 438
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v3.26.3
Inventory - Narrative (Details) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2026
Dec. 31, 2025
 [1]
Inventory [Line Items]    
Inventories - current $ 134,252 $ 101,060
Inventories-noncurrent 341,584 $ 342,232
Inventory incurred prior to FDA approval $ 32,300  
Minimum    
Inventory [Line Items]    
Period of lower average per unit cost of materials (in months) 3 months  
Maximum    
Inventory [Line Items]    
Period of lower average per unit cost of materials (in months) 25 months  
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Income Taxes
 9 Months Ended
Sep. 30, 2026
Income Tax Disclosure [Abstract]  
Income Taxes
Note 13. Income Taxes
For the three and nine months ended September 30, 2026 and 2025, we recorded the following provisions for income taxes and effective tax rates as compared to our (loss) income before provision for income taxes (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
(Loss) income before provision for income taxes$(688,848)$482,308 $406,266 $1,274,510 
Provision for income taxes95,955 58,139 302,134 287,139 
Effective tax rate(13.9)%12.1%74.4%22.5%
Our effective tax rates for the three and nine months ended September 30, 2026 were unfavorably impacted by a one-time non-deductible charge of $1.23 billion associated with the acquisition of Vega and a net increase in valuation allowances against certain U.S. federal and state deferred tax assets. This was partially offset by tax benefits associated with the generation of tax credits, stock compensation related tax deductions and foreign tax effects. In addition, our effective tax rate for the nine months ended September 30, 2026 was favorably impacted by changes in unrecognized tax benefits.
Our effective tax rate for the three months ended September 30, 2025 was favorably impacted by a net decrease in our valuation allowance against certain U.S. federal deferred tax assets, resulting from the 2025 U.S. tax law changes described below. Our effective tax rate for the nine months ended September 30, 2025 was unfavorably impacted by an increase in our valuation allowance against certain U.S. federal and state deferred tax assets. This was partially offset by tax rate benefits associated with the generation of tax credits, the effect of cross-border tax laws and a decrease in a prior year valuation allowance against certain U.S. federal deferred tax assets, resulting from the 2025 U.S. tax law changes.
The effective tax rates for the three and nine months ended September 30, 2026 were unfavorable as compared to the three and nine months ended September 30, 2025 primarily due to the one-time non-deductible charge of $1.23 billion associated with the acquisition of Vega.
We accrue interest and penalties related to unrecognized tax benefits as a component of the provision for income taxes.
One or more of our legal entities file income tax returns in the U.S. and in certain foreign jurisdictions. Our income tax returns may be examined by tax authorities in those jurisdictions. Significant disputes may arise with tax authorities involving issues such as the timing and amount of deductions, the use of tax credits and allocations of income and expenses among various tax jurisdictions because of differing interpretations of tax laws and regulations and relevant facts. We were under U.S. federal audit for the 2021 tax year; during the first quarter of 2026, the federal audit for tax year 2021 was completed with no material matters identified.
The Organization for Economic Cooperation and Development Pillar 2 guidelines, supported by over 130 countries worldwide, establish a 15% global minimum tax on adjusted financial results. Pillar 2 legislation has been enacted in multiple jurisdictions in which we operate and became effective beginning in 2024. We have evaluated the impact of Pillar 2 on our business, and determined there are no material impacts on our effective tax rate at this time. We will continue to monitor additional enactments and guidance as they occur and assess any future impacts in the period they become effective.
In July 2025, the U.S. enacted the One Big Beautiful Bill Act (“OBBBA”), which modified certain provisions of the Tax Cuts and Jobs Act of 2017, including those related to the expensing of domestic research and development costs, the deduction for foreign-derived intangible income, and the global intangible low-taxed income regime. The OBBBA also introduced multiple elections related to the treatment of domestic research and development expenditures. As a result of these changes, we expect to fully deduct certain expenditures for which deferred tax assets had previously been recorded and, accordingly, no longer maintain a valuation allowance against such amounts. The absence of these deferred tax assets and related valuation allowance continues to have a favorable impact on our effective tax rate for the current period.
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Income Taxes (Tables)
 9 Months Ended
Sep. 30, 2026
Income Tax Disclosure [Abstract]  
Schedule of Effective Income Tax Rate Reconciliation
For the three and nine months ended September 30, 2026 and 2025, we recorded the following provisions for income taxes and effective tax rates as compared to our (loss) income before provision for income taxes (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
(Loss) income before provision for income taxes$(688,848)$482,308 $406,266 $1,274,510 
Provision for income taxes95,955 58,139 302,134 287,139 
Effective tax rate(13.9)%12.1%74.4%22.5%
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v3.26.3
Employee Benefit Plans - Schedule of Net Periodic Benefit Cost (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Retirement Benefits [Abstract]        
Service cost $ 4,101 $ 4,068 $ 12,231 $ 11,674
Interest cost 667 489 2,050 1,402
Expected return on plan assets (1,874) (1,867) (5,761) (5,358)
Amortization of prior service cost 102 228 314 648
Amortization of actuarial losses 122 357 374 1,025
Net periodic benefit cost $ 3,118 $ 3,275 $ 9,208 $ 9,391
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Acquisitions
 9 Months Ended
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Business Combination, Asset Acquisition, Transaction between Entities under Common Control, and Joint Venture Formation [Abstract]  
Acquisitions
Note 6. Acquisitions

Vega Therapeutics, Inc. (“Vega”)
On June 8, 2026, we entered into an agreement with Star Therapeutics LLC (“Star”) to acquire all of the outstanding shares of capital stock of Vega, a clinical-stage drug development company and wholly owned subsidiary of Star developing novel antibody therapies for rare blood disorders, focusing on von Willebrand disease. We completed the acquisition on July 6, 2026, for cash consideration of $1.25 billion.
Vega’s lead molecule, latarcibart (formerly VGA039), is a first-in-class anti–Protein S monoclonal antibody in Phase 3 development for the treatment of von Willebrand disease, the most common inherited bleeding disorder. We accounted for the Vega transaction as an asset acquisition under U.S. GAAP because the latarcibart asset represents substantially all of the fair value of the gross assets acquired.
In addition to the $1.25 billion closing cash consideration, we incurred $16.7 million of direct transaction costs that were included in the total consideration allocated to the acquired net assets. Of the $1.267 billion in total consideration, $1.232 billion was allocated to the latarcibart asset, an acquired in-process research and development (“IPR&D”) asset. The remaining $35.3 million of total consideration was allocated to the net assets acquired, including $37.5 million of a deferred tax asset, offset by liabilities assumed. As the acquired IPR&D asset does not have an alternative future use at the acquisition date, we recognized the full amount of $1.232 billion as research and development expenses on our condensed consolidated statements of operations during the three months and nine months ended September 30, 2026.
Star is eligible to receive up to $750 million in additional payments upon the achievement of specified annual net sales milestones in the U.S. for latarcibart. Because the transaction was accounted for as an asset acquisition, the contingent milestone payments were not recognized as of the acquisition date. We will recognize any additional consideration when the related contingency is resolved, and the U.S. net sales milestones are met. No amounts were recorded for the contingent milestone payments as of September 30, 2026.
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v3.26.3
Property and Equipment, net - Narrative (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended 12 Months Ended 19 Months Ended
May 31, 2024
Sep. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Dec. 31, 2025
Dec. 31, 2025
Property and equipment, net                
Payments to acquire property, plant, and equipment $ 48,700              
Asset impairment and related disposal costs   $ 0 $ 23,200 $ 0 $ 23,214 $ 0 $ 76,300  
Construction in progress                
Property and equipment, net                
Property, plant, and equipment, capitalized               $ 28,600
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v3.26.3
Segment Reporting - Schedule of Consolidated Net (Loss) Income (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Mar. 31, 2026
Sep. 30, 2025
Jun. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues $ 1,557,204     $ 1,365,980     $ 4,503,919 $ 3,634,407
Costs, expenses and other:                
Cost of sales (including definite-lived intangible amortization) 108,744     99,001     318,224 250,955
Contract dispute settlement 0     0     0 (242,251)
Loss (gain) on change in fair value of acquisition-related contingent consideration 892     (12,204)     3,223 22,129
Net (loss) income (784,803) $ 585,605 $ 303,330 424,169 $ 404,999 $ 158,203 104,132 987,371
Reportable Segment                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 1,557,204     1,365,980     4,503,919 3,634,407
Costs, expenses and other:                
Cost of sales (including definite-lived intangible amortization) 108,744     99,001     318,224 250,955
Contract dispute settlement 0     0     0 (242,251)
Research and development - internal 283,647     250,140     812,438 715,171
Research and development - external 270,746     256,344     762,208 695,459
Other research and development 1,237,263     100     1,249,863 28,150
Sales and marketing 296,885     272,302     842,200 786,265
General and administrative 67,388     56,779     201,895 199,529
Asset impairment and related disposal costs 0     0     23,214 0
Loss (gain) on change in fair value of acquisition-related contingent consideration 892     (12,204)     3,223 22,129
Other segment items 76,442     19,349     186,522 191,629
Net (loss) income (784,803)     424,169     104,132 987,371
Net sales                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 1,316,413     1,149,856     3,909,046 3,131,544
Net sales | Reportable Segment                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 1,316,413     1,149,856     3,909,046 3,131,544
Product royalty revenues                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 190,991     171,124     516,873 452,863
Product royalty revenues | Reportable Segment                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 190,991     171,124     516,873 452,863
Milestone and contract revenues                
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
Total revenues 49,800     45,000     78,000 50,000
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Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]                
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Segment Reporting - Schedule of Property and Equipment, Net by Geographic Areas (Details) - USD ($)
$ in Thousands
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Dec. 31, 2025
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]    
Total property and equipment, net $ 701,101 $ 730,885 [1]
United States    
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]    
Total property and equipment, net 397,790 406,829
Switzerland    
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]    
Total property and equipment, net 291,013 309,802
Other countries    
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]    
Total property and equipment, net $ 12,298 $ 14,254
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Inventory - Schedule of Inventory Balances (Details) - USD ($)
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Dec. 31, 2025
Inventory Disclosure [Abstract]    
Raw materials $ 48,868 $ 27,860
API and work-in-process 355,581 343,678
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Total inventory $ 475,836 $ 443,292
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v3.26.3
Employee Benefit Plans
 9 Months Ended
Sep. 30, 2026
Retirement Benefits [Abstract]  
Employee Benefit Plans
Note 15. Employee Benefit Plans
Defined Contribution Plans
We have a defined contribution plan qualified under Section 401(k) of the Internal Revenue Code covering all U.S. employees and defined contribution plans for other Incyte employees in Europe and Japan. Employees may contribute a portion of their compensation, which is then matched by us, subject to certain limitations. Defined contribution expense for the three and nine months ended September 30, 2026 was $6.4 million and $19.1 million, respectively. Defined contribution expense for the three and nine months ended September 30, 2025 was $5.8 million and $17.3 million, respectively.
Defined Benefit Pension Plans
We have defined benefit pension plans for our employees in Europe which provide benefits to employees upon retirement, death or disability. The assets of the pension plans are held in collective investment accounts represented by the cash surrender value of an insurance policy and are classified as Level 2 within the fair value hierarchy.
The net periodic benefit cost was as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Service cost$4,101 $4,068 $12,231 $11,674 
Interest cost667 489 2,050 1,402 
Expected return on plan assets(1,874)(1,867)(5,761)(5,358)
Amortization of prior service cost102 228 314 648 
Amortization of actuarial losses122 357 374 1,025 
Net periodic benefit cost$3,118 $3,275 $9,208 $9,391 
The components of net periodic benefit cost other than the service cost component are included in Other, net on the condensed consolidated statements of operations. We expect to contribute a total of $12.6 million to the pension plans in 2026 inclusive of the amounts contributed to the plan during the current period.
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v3.26.3
Collaborative and Other Relationships - Prelude (Details) - USD ($)
$ / shares in Units, $ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended
Nov. 30, 2025
Sep. 30, 2026
Dec. 31, 2025
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
License Agreements            
Research and development   $ 1,791,656   $ 506,584 $ 2,824,509 $ 1,438,780
Long term equity investments   91,162 $ 47,991 [1]   91,162  
Investment in Prelude            
License Agreements            
Payments to acquire equity securities $ 25,000          
Investment owned (in shares) 6,250,000          
Per share price (in USD per share) $ 4.00          
Long term equity investments $ 7,900 24,400 18,100   24,400  
Unrealized (loss) gain on equity investments   $ (8,900)     $ 6,300  
Prelude            
License Agreements            
Payment to acquire license agreement 60,000          
Upfront payment under license agreement 35,000          
Research and development     $ 17,100      
Milestone payment made under license agreement 100,000          
Prelude | Clinical And Regulatory Milestones And Single Digit Royalties On Global Net Sales | Maximum            
License Agreements            
Additional milestone payments under the license agreement $ 775,000          
[1] The condensed consolidated balance sheet at December 31, 2025 has been derived from the audited consolidated financial statements at that date.
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v3.26.3
Collaborative and Other Relationships - Novartis (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended 203 Months Ended
May 11, 2025
Nov. 30, 2009
Sep. 30, 2026
Sep. 30, 2025
Mar. 31, 2025
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Dec. 31, 2025
License Agreements                  
Contract dispute settlement     $ 0 $ 0   $ 0 $ 242,251    
Total revenues     1,557,204 1,365,980   4,503,919 3,634,407    
United States                  
License Agreements                  
Total revenues     1,434,977 1,261,261   4,166,555 3,375,171    
JAKAFI                  
License Agreements                  
Total revenues     826,501 791,071   2,400,915 2,264,271    
Novartis | JAKAFI                  
License Agreements                  
Royalties payable         $ 537,100        
Litigation settlement, amount awarded to other party $ 280,000                
Royalty rate payable, percent reduction (as a percent) 50.00%                
Decrease in royalties payable         $ 14,900        
Contract dispute settlement             242,200    
Novartis | JAKAFI | United States                  
License Agreements                  
Royalties payable     20,200     20,200   $ 20,200 $ 20,300
Total revenues     20,200 19,300   56,300 67,800    
Novartis | JAKAVI                  
License Agreements                  
Total revenues     132,500 125,600   362,200 327,500    
Novartis | TABRECTA                  
License Agreements                  
Total revenues     $ 6,800 $ 6,500   $ 19,500 $ 19,600    
Maximum | Novartis | JAKAVI                  
License Agreements                  
Royalty payments on future global net sales (as a percent)           14.00%      
Minimum | Novartis | JAKAVI                  
License Agreements                  
Royalty payments on future global net sales (as a percent)           12.00%      
Development Milestones | Novartis                  
License Agreements                  
Amount recognized and received for the achievement of a predefined milestone               157,000  
Development Milestones | Maximum | Novartis                  
License Agreements                  
Upfront and immediate milestone payment to be received under license agreement   $ 174,000              
Regulatory Milestones | Novartis                  
License Agreements                  
Amount recognized and received for the achievement of a predefined milestone               345,000  
Regulatory Milestones | Maximum | Novartis                  
License Agreements                  
Upfront and immediate milestone payment to be received under license agreement   495,000              
Commercialization Milestones | Novartis                  
License Agreements                  
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Commercialization Milestones | Maximum | Novartis                  
License Agreements                  
Upfront and immediate milestone payment to be received under license agreement   500,000              
Development and Regulatory Milestones | Maximum | Novartis | GVHD                  
License Agreements                  
Upfront and immediate milestone payment to be received under license agreement   $ 75,000              
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v3.26.3
Inventory
 9 Months Ended
Sep. 30, 2026
Inventory Disclosure [Abstract]  
Inventory
Note 7. Inventory
Our inventory balance consists of the following (in thousands):
September 30,
2026		December 31,
2025
Raw materials$48,868 $27,860 
API and work-in-process355,581 343,678 
Finished goods71,387 71,754 
Total inventory$475,836 $443,292 
Inventories, stated at the lower of cost and net realizable value, consist of raw materials, active pharmaceutical ingredients (“API”), work-in-process, and finished goods, inclusive of freight and inventoriable overhead. At September 30, 2026, $134.3 million of inventory was classified as current on the condensed consolidated balance sheet as we expect this inventory to be consumed for commercial use within the next twelve months. At September 30, 2026, $341.6 million of inventory was classified as non-current on the condensed consolidated balance sheet as we do not expect this inventory to be consumed for commercial use within the next twelve months. We obtain some inventory components from a limited number of suppliers due to technology, availability, price, quality or other considerations. The loss of a supplier, the deterioration of our relationship with a supplier, or any unilateral violation of the contractual terms under which we are supplied components by a supplier could adversely affect our total revenues and gross margins.
We capitalize inventory after regulatory approval as the related costs are expected to be recoverable through the commercialization of the product. Costs incurred prior to regulatory approval are recorded as research and development expense in our condensed consolidated statements of operations. At September 30, 2026, inventory with approximately $32.3 million of product costs incurred prior to regulatory approval had not yet been sold. We expect to sell the pre-commercialization inventory over the next 3 to 25 months and, as a result, cost of sales will reflect a lower average per unit cost of materials.
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Inventory Disclosure [Abstract]  
Schedule of Inventory
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API and work-in-process355,581 343,678 
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v3.26.3
Commitments and Contingencies
 9 Months Ended
Sep. 30, 2026
Commitments and Contingencies Disclosure [Abstract]  
Commitments and Contingencies
Note 16. Commitments and Contingencies
Commitments
In August 2021, we entered into a revolving credit and guaranty agreement, which was subsequently amended in May 2023 and June 2024 (as amended, the “Credit Agreement”), among Incyte Corporation, as borrower, our subsidiary Incyte Holdings Corporation, as a guarantor, a group of lenders (the “Lenders”), and J.P. Morgan Chase Bank, N.A., as administrative agent. Under the Credit Agreement, the Lenders have committed to provide an unsecured revolving credit facility in an aggregate principal amount of up to $500.0 million. The June 2024 amendment to the Credit Agreement extended the maturity date of the revolving credit facility from August 2024 to June 2027. We may increase the maximum revolving commitments or add one or more incremental term loan facilities to the Credit Agreement, subject to obtaining commitments from any participating lenders and certain other conditions, in an amount not to exceed (1) $250.0 million plus (2) an additional amount, so long as after giving effect to the incurrence of such additional amount, our pro forma consolidated leverage ratio would not exceed 0.25:1.00 above our consolidated leverage ratio in effect immediately prior to giving effect to such increase.
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Contingencies
In the ordinary course of our business, we may become involved in lawsuits, proceedings, and other disputes, including commercial, intellectual property, regulatory, employment, and other matters. The outcome of these disputes, regardless of the merits, is inherently uncertain and it is possible that an unfavorable resolution of these matters could adversely affect us, our results of operations, financial condition or cash flows. We record a reserve for these matters when it is both probable that a liability has been incurred and the amount of the loss can be reasonably estimated.
We have entered into the collaboration agreements described in Note 8, as well as various other collaboration agreements that are not individually, or in the aggregate, significant to our operating results or financial condition at this time. We may in the future seek to license additional rights relating to technologies or drug development candidates in connection with our drug discovery and development programs. Under these agreements, we may be required to pay upfront fees, milestone payments, and royalties on sales of future products.
We brought a lawsuit against CMS alleging that a regulation issued by CMS on the definition of “line extension” for purposes of the Medicaid rebate program was too broad and had the unintended consequence of treating OPZELURA as a “line extension” of JAKAFI under this program. In the second quarter of 2026, we reached an agreement with CMS to resolve our litigation related to the application of Medicaid rebate rules to OPZELURA (ruxolitinib) cream. Under the agreement, CMS will not apply the line extension regulations to OPZELURA as if it were a line extension of JAKAFI (ruxolitinib). In the second quarter of 2026, we recorded a one-time, non-cash benefit of $246.0 million in net sales on the condensed consolidated statements of operations, associated with the reversal of previously established accrual balances through March 31, 2026, related to liabilities associated with the potential application of the line extension regulations to OPZELURA. We no longer accrue for the potential application of the line extension regulations to OPZELURA.
In addition, we have various patent disputes and litigation initiated by us related to potential generic or other competition for our products, as described below under Part II, Item 1A. “Risk Factors—Risks Relating to Commercialization of Our Products— Competition for our products could harm our business and result in a decrease in our revenue.”
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v3.26.3
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($)
$ in Thousands
Sep. 30, 2026
Dec. 31, 2025
Statement of Financial Position [Abstract]    
Marketable securities-amortized cost $ 585,611 $ 480,793
Marketable securities-allowance for credit losses $ 0 $ 0
Preferred stock, par value (in USD per share) $ 0.001 $ 0.001
Preferred stock, shares authorized (in shares) 5,000,000 5,000,000
Preferred stock, shares issued (in shares) 0 0
Preferred stock, shares outstanding (in shares) 0 0
Common stock, par value (in USD per share) $ 0.001 $ 0.001
Common stock, shares authorized (in shares) 400,000,000 400,000,000
Common stock, shares issued (in shares) 204,002,500 198,460,009
Common stock, shares outstanding (in shares) 204,002,500 198,460,009
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v3.26.3
Revenues (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Jun. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Revenues          
Total revenues $ 1,557,204   $ 1,365,980 $ 4,503,919 $ 3,634,407
Net sales          
Revenues          
Total revenues 1,316,413   1,149,856 3,909,046 3,131,544
JAKAFI          
Revenues          
Total revenues 826,501   791,071 2,400,915 2,264,271
OPZELURA          
Revenues          
Total revenues 254,880   187,968 847,631 471,172
OPZELURA | U.S. Centers for Medicare and Medicaid Services          
Revenues          
Loss contingency accrual, reversal of loss   $ 246,000   246,000  
ICLUSIG          
Revenues          
Total revenues 33,527   37,582 103,384 99,855
PEMAZYRE          
Revenues          
Total revenues 21,179   22,741 67,140 63,373
MINJUVI/MONJUVI          
Revenues          
Total revenues 54,630   41,990 157,543 102,672
NIKTIMVO          
Revenues          
Total revenues 67,368   45,830 182,765 95,597
ZYNYZ          
Revenues          
Total revenues 58,328   22,674 149,668 34,604
Product royalty revenues          
Revenues          
Total revenues 190,991   171,124 516,873 452,863
JAKAVI          
Revenues          
Total revenues 132,458   125,645 362,204 327,504
OLUMIANT          
Revenues          
Total revenues 39,052   37,111 113,938 101,393
TABRECTA          
Revenues          
Total revenues 6,833   6,513 19,506 19,558
Other          
Revenues          
Total revenues 12,648   1,855 21,225 4,408
Milestone and contract revenues          
Revenues          
Total revenues $ 49,800   $ 45,000 $ 78,000 $ 50,000
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Concentration of Credit Risk and Current Expected Credit Losses - Schedule of Concentration of Credit Risk Related to Collaborative Partners (Details) - Revenue, Product and Service Benchmark - Customer Concentration Risk
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Customer A        
Concentration of risk        
Percentage of concentration risk 10.00% 14.00% 11.00% 13.00%
Customer B        
Concentration of risk        
Percentage of concentration risk 22.00% 20.00% 21.00% 21.00%
Customer C        
Concentration of risk        
Percentage of concentration risk 18.00% 18.00% 19.00% 19.00%
Customer D        
Concentration of risk        
Percentage of concentration risk 12.00% 10.00% 11.00% 10.00%
Customer E        
Concentration of risk        
Percentage of concentration risk 11.00% 11.00% 10.00% 10.00%
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Accrued and Other Current Liabilities (Details) - USD ($)
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v3.26.3
Segment Reporting - Schedule of Long-Lived Assets by Geographic Areas (Details) - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]        
Total revenues $ 1,557,204 $ 1,365,980 $ 4,503,919 $ 3,634,407
United States        
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]        
Total revenues 1,434,977 1,261,261 4,166,555 3,375,171
Europe        
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]        
Total revenues 107,374 100,306 304,934 247,744
Other countries        
Segment Reporting, Entity-Wide Information Not Provided as Part of Reportable Segment, Geographical Area, Revenue and Long-Lived Asset [Line Items]        
Total revenues $ 14,853 $ 4,413 $ 32,430 $ 11,492
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v3.26.3
Summary of Significant Accounting Policies (Policies)
 9 Months Ended
Sep. 30, 2026
Accounting Policies [Abstract]  
Basis of presentation
Basis of presentation
The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”) for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. The condensed consolidated balance sheet as of September 30, 2026, the condensed consolidated statements of operations, comprehensive income (loss), and stockholders’ equity for the three and nine months ended September 30, 2026 and 2025, and the condensed consolidated statements of cash flows for the nine months ended September 30, 2026 and 2025, are unaudited, but include all adjustments, consisting only of normal recurring adjustments, which we consider necessary for a fair presentation of the financial position, operating results and cash flows for the periods presented. The condensed consolidated balance sheet at December 31, 2025 has been derived from our audited consolidated financial statements.
Although we believe that the disclosures in these financial statements are adequate to make the information presented not misleading, certain information and footnote information normally included in financial statements prepared in accordance with U.S. GAAP have been condensed or omitted pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”).
Results for any interim period are not necessarily indicative of results for any future interim period or for the entire year. The accompanying financial statements should be read in conjunction with the financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2025.
Principles of Consolidation
Principles of Consolidation. The condensed consolidated financial statements include the accounts of Incyte Corporation and our wholly owned subsidiaries. All inter-company accounts, transactions, and profits have been eliminated in consolidation.
Use of Estimates
Use of Estimates. The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. On an ongoing basis, we evaluate our estimates. We base our estimates on historical experience and various other assumptions that we believe to be reasonable under the circumstances, the results of which form our basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results could differ from those estimates.
Change in Accounting Principle
Change in Accounting Principle
Effective July 1, 2026, we changed our inventory costing method for commercial product manufactured by third-party contract manufacturers from the specific identification method to the first-in, first-out (“FIFO”) method. Following the change, all inventories are accounted for under the FIFO method. We believe this change in accounting method is preferable as it (i) aligns accounting policies with the predominant inventory costing method used by industry peers, improving comparability for investors; (ii) is consistent with how we manage our business; and (iii) provides a single, uniform inventory costing methodology across all of our inventory. This change in accounting principle did not have a material effect on inventory or cost of sales for all periods presented; nor did it have a material impact on opening retained earnings. Therefore, prior comparative financial statements have not been restated.
Recent Accounting Pronouncements and Regulatory Updates
Recent Accounting Pronouncements and Regulatory Updates
In November 2024, the Financial Accounting Standards Board (“FASB”) issued ASU No. 2024-03, “Disaggregation of Income Statement Expenses (DISE).” This new guidance applies to all public entities and requires disclosures about specific types of expenses included in the expense captions presented on the face of the income statement as well as disclosures about selling expenses. Public entities must adopt the new standard prospectively for fiscal years beginning after December 15, 2026, and interim reporting periods beginning after December 15, 2027. Early adoption and retrospective application are permitted. We are currently evaluating the impact ASU No. 2024-03 will have on our consolidated financial statements and related disclosures.
In July 2025, the FASB issued ASU No. 2025-05, “Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses for Accounts Receivable and Contract Assets.” This amended guidance applies to all entities and aims to simplify the estimation of expected credit losses for current accounts receivable and contract assets by providing a practical expedient for all companies. The amendments are effective for annual reporting periods beginning after December 15, 2025 and interim reporting periods within those annual periods. We formally adopted ASU 2025-05, effective January 1, 2026, and elected the practical expedient provided to all companies. This adoption and related practical expedient election did not have and is not expected to have a material impact on our consolidated financial statements and related disclosures.
In September 2025, the FASB issued ASU No. 2025-06, “Intangibles - Goodwill and Other - Internal-Use (Subtopic 350-40): Targeted Improvements to the Accounting for Internal-Use Software.” This amended guidance applies to all entities and serves to modernize the accounting for software costs that are accounted for under Subtopic 350-40, Intangibles - Goodwill and Other - Internal-Use Software (referred to as “internal-use software”). The amendments in this update are effective for all entities for annual reporting periods beginning after December 15, 2027, and interim reporting periods within those annual reporting periods. Early adoption is permitted as of the beginning of an annual reporting period. Entities may adopt the new guidance using a prospective, modified, or retrospective transition approach. We are currently evaluating the impact ASU No. 2025-06 will have on our consolidated financial statements and related disclosures.
In September 2025, the FASB issued ASU No. 2025-07, “Derivatives and Hedging (Topic 815) and Revenue from Contracts with Customers (Topic 606): Derivatives Scope Refinements and Scope Clarification for Share-Based Noncash Consideration from a Customer in a Revenue Contract.” This amended guidance applies to all entities and refines the scope of derivative accounting and clarifies rules for share-based noncash consideration in revenue contracts. Specifically, this update is intended to address concerns about the application of derivative accounting to contracts that have features based on the operations or activities of one of the parties to the contract and to reduce diversity in the accounting for share-based payments in revenue contracts. The amendments in this update are effective for all entities for annual reporting periods beginning after December 15, 2026, and interim reporting periods within those annual reporting periods. Early adoption is permitted. Entities may adopt the new guidance prospectively, or on a modified retrospective basis. We are currently evaluating the impact ASU No. 2025-07 will have on our consolidated financial statements and related disclosures.
In December 2025, the FASB issued ASU No. 2025-10, “Government Grants (Topic 832): Accounting for Government Grants Received by Business Entities.” This accounting standard update establishes specific rules for the recognition, measurement, and presentation of government grants received by business entities. For public business entities, this amended guidance is applicable for fiscal years beginning after December 15, 2028, including interim periods within those fiscal years. Early adoption is permitted. Entities may adopt the new guidance using a modified prospective, modified retrospective, or full retrospective approach. We are currently evaluating the impact ASU No. 2025-10 will have on our consolidated financial statements and related disclosures.
In December 2025, the FASB issued ASU No. 2025-11, “Interim Reporting (Topic 270): Narrow-Scope Improvements.” The amendments in this update aim to enhance the guidance in Topic 270, Interim Reporting, by improving the navigability of the required interim disclosures and clarifying when that guidance is applicable. The amendments also provide additional guidance on what disclosures should be provided in interim reporting periods. Lastly, this updated guidance incorporates a principle that requires entities to disclose significant events since the end of the last annual reporting period. The amendments in this update apply to all entities that provide interim financial statements and notes in accordance with U.S. GAAP. For public business entities, this amended guidance is effective for interim reporting periods within annual reporting periods beginning after December 15, 2027. Early adoption is permitted, and the amendments in this update can be applied either prospectively or retrospectively to any or all periods presented in the financial statements. We are currently evaluating the impact ASU No. 2025-11 will have on our future condensed consolidated financial statements and related disclosures.
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v3.26.3
Segment Information
 9 Months Ended
Sep. 30, 2026
Segment Reporting [Abstract]  
Segment Information
Note 17. Segment Information
We operate in one operating segment, and therefore one reportable segment, focused on the global discovery, development and commercialization of proprietary therapeutics. We manage business activities on a consolidated basis through the development and commercialization of oncology and dermatology products, which are sold to U.S. and international customers. Our determination that we operate as a single operating segment is consistent with the financial information regularly reviewed by the chief operating decision maker for purposes of evaluating performance, allocating resources, setting incentive compensation targets, and planning and forecasting for future periods. Our chief operating decision maker is the Chief Executive Officer.
The accounting policies for our single operating segment are the same as those described in the summary of significant accounting policies in our Annual Report on Form 10-K for the year ended December 31, 2025. Our single operating segment generates net sales from the development and commercialization of oncology and dermatology pharmaceutical products, which are developed by our research and development department, as well as from product royalties, milestone and contract revenues from the out-licensing of our intellectual property to third parties.
For our segment, the chief operating decision maker uses net income or loss, that also is reported on the condensed consolidated statements of operations as consolidated net income, to allocate resources (including employees, property, and financial resources), predominantly during the annual budget and forecasting process. The chief operating decision maker also uses consolidated net income or loss, along with non-financial inputs and qualitative information, to evaluate our performance, establish compensation, monitor budget versus actual results, and decide the level of investment in our various operating activities and other capital allocation activities. The measure of segment assets is reported on the condensed consolidated balance sheet as total consolidated assets.
Net (loss) income for our segment was as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Net sales$1,316,413 $1,149,856 $3,909,046 $3,131,544 
Product royalty revenues190,991 171,124 516,873 452,863 
Milestone and contract revenues49,800 45,000 78,000 50,000 
Total revenues1,557,204 1,365,980 4,503,919 3,634,407 
Costs, expenses and other:
Cost of sales (including definite-lived intangible amortization)108,744 99,001 318,224 250,955 
Contract dispute settlement— — — (242,251)
Research and development - internal1
283,647 250,140 812,438 715,171 
Research and development - external2
270,746 256,344 762,208 695,459 
Other research and development3
1,237,263 100 1,249,863 28,150 
Sales and marketing296,885 272,302 842,200 786,265 
General and administrative67,388 56,779 201,895 199,529 
Asset impairment and related disposal costs— — 23,214 — 
Loss (gain) on change in fair value of acquisition-related contingent consideration892 (12,204)3,223 22,129 
Other segment items4
76,442 19,349 186,522 191,629 
Net (loss) income$(784,803)$424,169 $104,132 $987,371 
1.Research and development - internal is comprised of internally generated costs such as salaries, travel, regulatory costs, lab costs and contracting.
2.Research and development - external is comprised of specific program spend with external vendors (i.e. contract manufacturing organizations, contract research organizations and lab vendors for clinical, technical operations and toxicology services).
3.Other research and development is comprised of all other costs including certain one-time costs resulting from the acquisition of IPR&D assets and one-time development milestone expenses.
4.Other segment items is comprised of interest income, interest expense, realized and unrealized gain (loss) on equity investments, other, net, and provision for income taxes.
Total Revenues by Geographic Location
Total revenues by geographic region were as follows (in thousands):
Three Months Ended September 30,Nine Months Ended September 30,
2026202520262025
United States$1,434,977 $1,261,261 $4,166,555 $3,375,171 
Europe107,374 100,306 304,934 247,744 
Other countries14,853 4,413 32,430 11,492 
Total revenues$1,557,204 $1,365,980 $4,503,919 $3,634,407 
Property and Equipment, Net by Geographic Location
Property and equipment, net by geographic location was as follows (in thousands):
September 30,
2026		December 31,
2025
United States$397,790 $406,829 
Switzerland291,013 309,802 
Other countries12,298 14,254 
Total property and equipment, net$701,101 $730,885 
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 9 Months Ended
Sep. 30, 2026
Risks and Uncertainties [Abstract]  
Schedule of Concentration of Credit Risk Related to Collaborative Partners
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Percentage of Total Net
Sales for the
Three Months Ended		Percentage of Total Net
Sales for the
Nine Months Ended
September 30,September 30,
2026202520262025
Customer A10 %14 %11 %13 %
Customer B22 %20 %21 %21 %
Customer C18 %18 %19 %19 %
Customer D12 %10 %11 %10 %
Customer E11 %11 %10 %10 %
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Collaborative and Other Relationships - Lilly – Baricitinib (Details) - USD ($)
$ in Thousands
 1 Months Ended 3 Months Ended 9 Months Ended 202 Months Ended
Dec. 31, 2009
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
License Agreements            
Total revenues   $ 1,557,204 $ 1,365,980 $ 4,503,919 $ 3,634,407  
Eli Lilly            
License Agreements            
Upfront payment received under license agreement           $ 100,000
Eli Lilly | OLUMIANT            
License Agreements            
Total revenues   $ 39,100 $ 37,100 $ 113,900 $ 101,400  
Development Milestones | Eli Lilly            
License Agreements            
Amount recognized and received for the achievement of a predefined milestone           149,000
Development Milestones | Maximum | Eli Lilly            
License Agreements            
Upfront and immediate milestone payment to be received under license agreement $ 150,000          
Regulatory Milestones | Eli Lilly            
License Agreements            
Amount recognized and received for the achievement of a predefined milestone           335,000
Regulatory Milestones | Maximum | Eli Lilly            
License Agreements            
Upfront and immediate milestone payment to be received under license agreement 365,000          
Commercialization Milestones | Eli Lilly            
License Agreements            
Amount recognized and received for the achievement of a predefined milestone           $ 50,000
Commercialization Milestones | Maximum | Eli Lilly            
License Agreements            
Upfront and immediate milestone payment to be received under license agreement $ 150,000          
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v3.26.3
Stock Compensation - Narrative (Details) - USD ($)
$ in Millions
 3 Months Ended 9 Months Ended
Sep. 30, 2026
Sep. 30, 2025
Sep. 30, 2026
Sep. 30, 2025
Stock compensation        
Stock compensation expense $ 69.8 $ 61.6 $ 201.2 $ 187.2
Dividend yield (as percent)     0.00%  
Shares Subject to Outstanding Options        
Stock compensation        
Stock option grant term (in years)     10 years  
Vesting period (in years)     4 years  
Percentage of units vesting at the end of each calendar year (as a percent)     25.00%  
Unrecognized compensation cost for nonvested option 43.0   $ 43.0  
Vesting period of recognition of the unrecognized compensation cost of nonvested awards (in years)     1 year 4 months 24 days  
Shares Subject to Outstanding Options | Share-based Payment Arrangement, Tranche One        
Stock compensation        
Vesting period (in years)     1 year  
Shares Subject to Outstanding Options | Share-based Payment Arrangement, Tranche Two        
Stock compensation        
Vesting period (in years)     36 months  
Restricted Stock Units (RSUs)        
Stock compensation        
Vesting period (in years)     4 years  
Percentage of units vesting at the end of each calendar year (as a percent)     25.00%  
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Stock compensation        
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Stock compensation        
Vesting period (in years)     3 years  
Performance Shares | Maximum        
Stock compensation        
Vesting period (in years)     6 years  
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Stock compensation        
Stock compensation expense 43.5 39.7 120.9 114.1
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Stock compensation        
Stock compensation expense $ 25.1 $ 21.0 $ 77.3 $ 70.5
Stock Incentive Plan 2010        
Stock compensation        
Shares reserved for future issuance (in shares) 74,953,475   74,953,475  
2024 Inducement Plan        
Stock compensation        
Shares reserved for future issuance (in shares) 2,000,000   2,000,000  
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v3.26.3
Employee Benefit Plans (Tables)
 9 Months Ended
Sep. 30, 2026
Retirement Benefits [Abstract]  
Schedule of Net Periodic Benefit Cost
The net periodic benefit cost was as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
Service cost$4,101 $4,068 $12,231 $11,674 
Interest cost667 489 2,050 1,402 
Expected return on plan assets(1,874)(1,867)(5,761)(5,358)
Amortization of prior service cost102 228 314 648 
Amortization of actuarial losses122 357 374 1,025 
Net periodic benefit cost$3,118 $3,275 $9,208 $9,391 
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v3.26.3
Other Comprehensive Income (Loss) (Tables)
 9 Months Ended
Sep. 30, 2026
Text Block [Abstract]  
Schedule of Accumulated Other Comprehensive Income (Loss)
The following tables summarize the activity related to each component of accumulated other comprehensive income (loss) during the nine months ended September 30, 2026 and 2025:
(Amounts presented net of taxes)Foreign Currency Translation Gains (Loss)Net Unrealized Gains (Losses) on Marketable SecuritiesDefined Benefit Pension PlansAccumulated Other Comprehensive Income (Loss)
Balances at January 1, 2026$51,433 $1,994 $(27,965)$25,462 
Other comprehensive loss before reclassifications(3,780)(8,914)— (12,694)
Net amount reclassified from accumulated other comprehensive income— — 688 688 
Net other comprehensive (loss) income(3,780)(8,914)688 (12,006)
Balances at September 30, 2026$47,653 $(6,920)$(27,277)$13,456 
(Amounts presented net of taxes)Foreign Currency Translation GainsNet Unrealized Gains on Marketable SecuritiesDefined Benefit Pension PlansAccumulated Other Comprehensive Income (Loss)
Balances at January 1, 2025$26,457 $346 $(39,924)$(13,121)
Other comprehensive income before reclassifications24,661 1,342 — 26,003 
Net amount reclassified from accumulated other comprehensive income— — 1,673 1,673 
Net other comprehensive income24,661 1,342 1,673 27,676 
Balances at September 30, 2025$51,118 $1,688 $(38,251)$14,555 
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v3.26.3
Revenues
 9 Months Ended
Sep. 30, 2026
Revenue from Contract with Customer [Abstract]  
Revenues
Note 3. Revenues
Revenues are recognized under guidance within ASC 606, Revenue from Contracts with Customers. The following table presents our disaggregated revenue for the periods presented (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2026202520262025
JAKAFI net sales1
$826,501 $791,071 $2,400,915 $2,264,271 
OPZELURA net sales2
254,880 187,968 847,631 471,172 
ICLUSIG net sales33,527 37,582 103,384 99,855 
PEMAZYRE net sales21,179 22,741 67,140 63,373 
MINJUVI/MONJUVI net sales54,630 41,990 157,543 102,672 
NIKTIMVO net sales67,368 45,830 182,765 95,597 
ZYNYZ net sales58,328 22,674 149,668 34,604 
Total net sales1,316,413 1,149,856 3,909,046 3,131,544 
JAKAVI product royalty revenues132,458 125,645 362,204 327,504 
OLUMIANT product royalty revenues39,052 37,111 113,938 101,393 
TABRECTA product royalty revenues6,833 6,513 19,506 19,558 
Other product royalty revenues12,648 1,855 21,225 4,408 
Total product royalty revenues190,991 171,124 516,873 452,863 
Milestone and contract revenues49,800 45,000 78,000 50,000 
Total revenues$1,557,204 $1,365,980 $4,503,919 $3,634,407 
1 2026 JAKAFI net sales include JAKAFI and JAKAFI XR following the launch of JAKAFI XR in the second quarter of 2026.
2 OPZELURA net sales for the nine months ended September 30, 2026 include $246.0 million related to our agreement with CMS to resolve our litigation related to the application of Medicaid rebate rules to OPZELURA. Refer to Note 16 for further information.
For further information on our revenue-generating contracts, refer to Note 8.
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