October 26, 2018

David Gryska
Chief Financial Officer
Incyte Corporation
1801 Augustine Cut-Off
Wilmington, DE 19803

       Re: Incyte Corporation
           Form 10-K for Fiscal Year Ended December 31, 2017
           Filed February 15, 2018
           Form 8-K Filed July 31, 2018
           File No. 001-12400

Dear Mr. Gryska:

       We have reviewed your filings and have the following comments. In some
of our
comments, we may ask you to provide us with information so we may better
understand your
disclosure.

       Please respond to these comments within ten business days by providing
the requested
information or advise us as soon as possible when you will respond. If you do
not believe our
comments apply to your facts and circumstances, please tell us why in your
response.

       After reviewing your response to these comments, we may have additional
comments.

Form 10-K for Fiscal Year Ended December 31, 2017

Item 8. Financial Statements and Supplementary Data
Consolidated Balance Sheets, page 78

1.    Your accrued and other current liabilities amounts represented 53% and
46% of total
      current liabilities as of December 31, 2017 and 2016, respectively.
Please separately
      disclose, either on your balance sheet or in a footnote, any item in
excess of five percent
      of total current liabilities, or explain to us how you have complied with
Rule 5-02.20 of
      Regulation S-X.
 David Gryska
Incyte Corporation
October 26, 2018
Page 2
Form 8-K Filed July 31, 2018

Exhibit 99.1
Reconciliation of GAAP Net Income (Loss) to Selected Non-GAAP Adjusted
Information, page
13

2.       Please disclose your purpose for including the adjustments for
"milestones received from
         new or existing partners" and "upfront consideration and milestones
paid to new or
         existing partners" in calculating the non-GAAP net income and non-GAAP
net income
         per share measures. Also, tell us how you determined these adjustments
do not substitute
         individually-tailored income or expense recognition methods for those
of GAAP. Refer to
         Question 100.04 of the Division's Non-GAAP Financial Measures
Compliance and
         Disclosure Interpretations.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

      You may contact Suying Li at (202) 551-3335 or Rufus Decker, Branch
Chief, at (202)
551-3769 with any questions.



                                                            Sincerely,
FirstName LastNameDavid Gryska
                                                            Division of
Corporation Finance
Comapany NameIncyte Corporation
                                                            Office of
Beverages, Apparel and
October 26, 2018 Page 2                                     Mining
FirstName LastName