Step 1: Go to www.envisionreports.com/INCY. Step 2: Click on Cast Your Vote or Request Materials. Step 3: Follow the instructions on the screen to log in. www.envisionreports.com/INCY Online Go to www.envisionreports.com/INCY or scan the QR code — login details are located in the shaded bar below. Stockholder Meeting Notice 03M55B + + Important Notice Regarding the Availability of Proxy Materials for the Incyte Corporation Stockholder Meeting to be Held on June 15, 2022 Under Securities and Exchange Commission rules, you are receiving this notice that the proxy materials for the annual stockholders’ meeting are available on the Internet. Follow the instructions below to view the materials and vote online or request a copy. The items to be voted on and location of the annual meeting are on the reverse side. Your vote is important! This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. The 2022 Proxy Statement and the Annual Report on Form 10-K for the year ended December 31, 2021 are available at: Obtaining a Copy of the Proxy Materials – If you want to receive a copy of the proxy materials, you must request one. There is no charge to you for requesting a copy. Please make your request as instructed on the reverse side on or before June 3, 2022 to facilitate timely delivery. 2NOT Easy Online Access — View your proxy materials and vote. When you go online, you can also help the environment by consenting to receive electronic delivery of future materials. Votes submitted electronically must be received by 11:59pm, (EDT), on June 14, 2022 Step 4: Make your selections as instructed on each screen for your delivery preferences. Step 5: Vote your shares.

Here’s how to order a copy of the proxy materials and select delivery preferences: Current and future delivery requests can be submitted using the options below. If you request an email copy, you will receive an email with a link to the current meeting materials. PLEASE NOTE: You must use the number in the shaded bar on the reverse side when requesting a copy of the proxy materials. — Internet – Go to www.envisionreports.com/INCY. Click Cast Your Vote or Request Materials. — Phone – Call us free of charge at 1-866-641-4276. — Email – Send an email to investorvote@computershare.com with “Proxy Materials Incyte Corporation” in the subject line. Include your full name and address, plus the number located in the shaded bar on the reverse side, and state that you want a paper copy of the meeting materials. To facilitate timely delivery, all requests for a paper copy of proxy materials must be received by June 3, 2022. Incyte Corporation’s Annual Meeting of Stockholders will be held on June 15, 2022 at 1815 Augustine Cut-off, Wilmington, Delaware 19803, at 1:00 p.m. (EDT). Proposals to be voted on at the meeting are listed below along with the Board of Directors’ recommendations. The Board of Directors recommend a vote FOR all the nominees listed and FOR Proposals 2 and 3: 1. Election of Directors: 01 – Julian C. Baker 02 – Jean-Jacques Bienaimé 03 – Otis W. Brawley 04 – Paul J. Clancy 05 – Jacqualyn A. Fouse 06 – Edmund P. Harrigan 07 – Katherine A. High 08 – Hervé Hoppenot 2. Approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers. 3. Ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for 2022. PLEASE NOTE – YOU CANNOT VOTE BY RETURNING THIS NOTICE. To vote your shares you must go online or request a paper copy of the proxy materials to receive a proxy card. If you wish to attend and vote at the meeting, please bring this notice with you. Stockholder Meeting Notice